CTP Phosphocholine cytidylyltransferase (CCT alpha, CCTa) | MyBioSource MBS620699 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CTP Phosphocholine cytidylyltransferase (CCT alpha, CCTa)

catalog :

MBS620699

quantity :

0.1 mL

price :

465 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS620699

products type :

Antibody

products full name :

CTP Phosphocholine cytidylyltransferase (CCT alpha, CCTa)

products short name :

CTP Phosphocholine cytidylyltransferase

products name syn :

Anti -CTP Phosphocholine cytidylyltransferase (CCT alpha, CCTa)

other names :

CTP:phosphocholine cytidylyltransferase; Choline-phosphate cytidylyltransferase A; choline-phosphate cytidylyltransferase A; CT A; CCT A; CCT-alpha; OTTHUMP00000208442; OTTHUMP00000208443; OTTHUMP00000208444; OTTHUMP00000208447; phosphorylcholine transferase A; CTP:phosphocholine cytidylyltransferase A; phosphate cytidylyltransferase 1, choline, alpha; CCT-alpha; CTP:phosphocholine cytidylyltransferase A; CCT A; CT A; Phosphorylcholine transferase A

other gene names :

PCYT1A; PCYT1A; CT; CTA; CCTA; CTPCT; PCYT1; CTPCT; PCYT1

uniprot entry name :

PCY1A_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

specificity :

Recognizes human CTP Phosphocholine Cytidylytransferase at 42kD.

purity :

Affinity Purified. Purified by Protein A affinity chromatography.

form :

Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA and 50% glycerol.

storage stability :

May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

tested application :

Western Blot (WB), Immunoprecipitation (IP). Other applications not tested.

app notes :

Suitable for use in Western Blot and Immunoprecipitation. Dilution: . Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1%. Tween-20 at 4 degree C with gentle shaking, overnight. Immunoprecipitation: 1:50. Optimal dilutions to be determined by the researcher.

other info1 :

Immunogen: Synthetic peptide corresponding to residues near the amino terminus of human CCT Alpha protein.

products categories :

Antibodies; Abs to Enzymes

products description :

CTP:phosphocholine cytidylyltransferase (CCT) is a critical enzyme that regulates the CDP-choline pathway for the biosynthesis of phosphatidylcholine. Three distinct CCT isoforms are found in mammals, including CCTa, CCTB2, and CCTB3 (1,2). CCTa is the major isoform that is expressed in most tissues (3). CCTa is essential in the synthesis and secretion of surfactant by alveolar epithelial cells and is important in maintaining the phosphatidylcholine level that regulates lipoprotein as- sembly and secretion in hepatocytes (4,5). CCTa is a major component in membrane biogenesis during cytokine secretion by stimulated macrophages (6). Monoubiquitination of CCTa prevents it from entering the nucleus and leads to its degradation by lysosome (7).

ncbi gi num :

575486

uniprot acc num :

P49585

ncbi mol weight :

41,731 Da

ncbi pathways :

Acetylcholine Synthesis Pathway (198820); Glycerophospholipid Metabolism Pathway (82989); Glycerophospholipid Metabolism Pathway (364); Metabolic Pathways (132956)

ncbi summary :

This gene belongs to the cytidylyltransferase family and is involved in the regulation of phosphatidylcholine biosynthesis. Mutations in this gene are associated with spondylometaphyseal dysplasia with cone-rod dystrophy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]

uniprot summary :

PCYT1A: Controls phosphatidylcholine synthesis. Homodimer. By phosphorylation. Belongs to the cytidylyltransferase family. Protein type: Transferase; EC 2.7.7.15; Lipid Metabolism - glycerophospholipid. Chromosomal Location of Human Ortholog: 3q29. Cellular Component: endoplasmic reticulum membrane; glycogen granule; cytosol. Molecular Function: choline-phosphate cytidylyltransferase activity; protein homodimerization activity; lipid binding. Biological Process: CDP-choline pathway; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine biosynthetic process. Disease: Spondylometaphyseal Dysplasia With Cone-rod Dystrophy

size1 :

0.1 mL

price1 :

465 USD

more info or order :

MyBioSource product webpage