PRG4 (Proteoglycan 4) | MyBioSource MBS620132 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PRG4 (Proteoglycan 4)

catalog :

MBS620132

quantity :

0.1 mg

price :

610 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS620132

products type :

Antibody

products full name :

PRG4 (Proteoglycan 4)

products short name :

PRG4

products name syn :

Anti -PRG4 (Proteoglycan 4)

other names :

proteoglycan 4 isoform B; Proteoglycan 4; proteoglycan 4; lubricin; OTTHUMP00000033580; OTTHUMP00000228757; OTTHUMP00000228758; superficial zone proteoglycan; megakaryocyte stimulating factor; megakaryocyte-stimulating factor; articular superficial zone protein; bG174L6.2 (MSF: megakaryocyte stimulating factor ); proteoglycan 4; Lubricin; Megakaryocyte-stimulating factor; Superficial zone proteoglycan

other gene names :

PRG4; PRG4; MSF; SZP; CACP; HAPO; JCAP; FLJ32635; bG174L6.2; MSF; SZP

uniprot entry name :

PRG4_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

specificity :

Recognizes PRG4, ~37kD. Species Crossreactivity: mouse

purity :

Affinity Purified. Purified by immunoaffinity chromatography.

form :

Supplied as a liquid in 0.1M Tris-Glycine, pH7.4, 150mM sodium chloride, 0.05% sodium azide.

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

Western Blot (WB), Immunocytochemistry (ICC)

app notes :

Suitable for use in Western Blot and Immunocytochemistry. Dilution: Western Blot: 1:2000. Immunocytochemistry: 1:500

other info1 :

Immunogen: Synthetic peptide corresponding to human PRG4 from C-terminal, conjugated to KLH. Species Sequence Homology: rat, human, primate and equine

other info2 :

Positive Control: Mouse Brain lysates

products categories :

Antibodies; Abs to Proteins

products description :

PRG4, Proteoglycan 4, is a human gene and is found in synovial tissue, cartilage, and liver. Small amounts are found in the lung. Isoform 1 is found in the kidney, lung, liver, heart and brain. The other Isoforms, C & D, are widely expressed. PRG4 is a lubricating glycoprotein containing chondroitin sulfate and keratan sulfate glycosaminoglycans. It is responsible for boundary lubrication at the cartilage surface. A disease associated with PRG4 is Jacobs's syndrome which is an autosomal recessive disorder.

ncbi gi num :

189181720

ncbi acc num :

NP_001121180.1

ncbi gb acc num :

NM_001127708.1

uniprot acc num :

Q92954

ncbi mol weight :

151,077 Da

ncbi summary :

The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

uniprot summary :

PRG4: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Defects in PRG4 are the cause of camptodactyly- arthropathy-coxa vara-pericarditis syndrome (CACP); also known as Jacobs syndrome. CACP is an autosomal recessive disorder. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure associated with noninflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1q25-q31. Cellular Component: extracellular space. Molecular Function: scavenger receptor activity; polysaccharide binding. Biological Process: receptor-mediated endocytosis; cell proliferation; negative regulation of interleukin-6 biosynthetic process; immune response; regulation of cell proliferation. Disease: Camptodactyly-arthropathy-coxa Vara-pericarditis Syndrome

size1 :

0.1 mg

price1 :

610 USD

more info or order :

MyBioSource product webpage