catalog number :
MBS620100
products full name :
SERPINB12 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 12)
products short name :
[SERPINB12]
products name syn :
[Anti -SERPINB12 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 12)]
other names :
[serpin B12; Serpin B12; serpin B12; OTTHUMP00000163678; OTTHUMP00000180649; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12; serpin peptidase inhibitor, clade B (ovalbumin), member 12]
other gene names :
[SERPINB12; SERPINB12; YUKOPIN; MGC119247; MGC119248]
uniprot entry name :
SPB12_HUMAN
specificity :
Recognizes human SERPINB12.
purity :
Affinity Purified. Purified by immunoaffinity chromatography.
form :
Supplied as a liquid in, pH 7.2, 0.02% sodium azide.
storage stability :
May be stored at 4°C for short term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing cap.
tested application :
Suitable for use in Western Blot. Other applications not tested.
app notes :
Western Blot: 1:500-1:1000. Optimal dilutions to be determined by the researcher.
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Synthetic peptide corresponding to residues 260-275 [SHSKDNLKGLEELERK] of the human SERPINB12 protein.
products categories :
Antibodies; Abs to Protease Inhibitors
products description :
Members of the human serpin family regulate a diverse array of serine and cysteine proteinases associated with essential biological processes such as fibrinolysis, coagulation, inflammation, cell mobility, cellular differentiation, and apoptosis. Most serpins are secreted and attain physiologic concentrations in the blood and extracellular fluids. However, a subset of the serpin superfamily, the ov-serpins, also resides intracellularly. A novel member of the human ov-serpin gene family, SERPINB12 is expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestines. SERPINB12 is an inhibitor of trypsin-like serine proteinases and a new functional member of the human ov-serpin family.
ncbi acc num :
NP_536722.1
ncbi gb acc num :
NM_080474.1
uniprot summary :
SERPINB12: Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator. Belongs to the serpin family. Ov-serpin subfamily. Protein type: Inhibitor. Chromosomal Location of Human Ortholog: 18q21.33. Cellular Component: extracellular space; cytoplasm. Molecular Function: serine-type endopeptidase inhibitor activity; enzyme binding. Biological Process: hemopoietic progenitor cell differentiation; negative regulation of protein catabolic process