Regenerating Protein 1 alpha (REG-1 alpha) | MyBioSource MBS620035 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Regenerating Protein 1 alpha (REG-1 alpha)

catalog :

MBS620035

quantity :

0.1 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS620035

products type :

Antibody

products full name :

Regenerating Protein 1 alpha (REG-1 alpha)

products short name :

Regenerating Protein 1 alpha

products name syn :

Anti -Regenerating Protein 1 alpha (REG-1 alpha)

other names :

regenerating islet-derived protein 3-alpha; Regenerating islet-derived protein 3-alpha; regenerating islet-derived protein 3-alpha; REG-3-alpha; reg III-alpha; PAP homologous protein; human proislet peptide; pancreatitis-associated protein 1; proliferation-inducing protein 34; proliferation-inducing protein 42; hepatocarcinoma-intestine-pancreas; pancreatic beta cell growth factor; hepatointestinal pancreatic protein; regenerating islet-derived protein III-alpha; regenerating islet-derived 3 alpha; Hepatointestinal pancreatic protein; HIP/PAP; Human proislet peptide; Pancreatitis-associated protein 1; Regenerating islet-derived protein III-alpha

other gene names :

REG3A; REG3A; HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III; HIP; PAP; PAP1; REG-3-alpha; HIP/PAP

uniprot entry name :

REG3A_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

specificity :

Recognizes human Regenerating Protein 1 alpha.

purity :

Affinity Purified. Purified by immunoaffinity chromatography.

form :

Supplied as a lyophilized powder from PBS, pH 7.2. No preservative added. Reconstitute with 100ul sterile ddH2O.

storage stability :

-20 degree C

tested application :

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

app notes :

Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry.

other info1 :

Immunogen: Recombinant corresponding to 156aa of human Regenerating Protein 1 alpha expressed in E. coli.

products categories :

Antibodies; Abs to Proteins

products description :

Reg protein was shown to be stimulated during the regeneration of pancreatic islets. Since then, many Reg-related proteins have been identified in humans and other animals. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. These Reg-related proteins are classified into four subfamilies according to their aa sequences, but they share a similar structure and physiological function. Reg is a growth factor for pancreatic beta cells and suggests that the administration of Reg could be used as another therapeutic approach for diabetes mellitus. Human REG cDNA encodes a 166aa protein with a 22aa signal peptide. The aa sequence of human REG has 68% homology to that of rat Reg. Reg 1 was found to be expressed mainly in pancreatic beta and acinoductular cells as well as gastric fundic enterochromaffin-like (ECL) cells. Reg I production in ECL cells is stimulated by gastrin, as well as by the proinflammatory cytokine, cytokine-induced neutrophil chemoattractant (CINC)-2Beta. In patients with chronic hypergastrinemia, Reg production is stimulated with the increased proliferation of gastric mucosal cells. Patients with Helicobacter pylori infection also showed increased Reg production in the gastric mucosa, partly via increased plasma gastrin concentration and partly via increased proinflammatory cytokine production. The serum concentration of the reg-protein was significantly higher in patients with various pancreatic diseases than in normal controls, and was also significantly higher in patients with acute pancreatitis or chronic relapsing pancreatitis than in patients with chronic pancreatitis. Furthermore, the serum PSP/reg-protein concentration was also significantly increased in liver cirrhosis, choledocholit-hiasis and various cancers of the digestive system.

ncbi gi num :

4505605

ncbi acc num :

NP_002571.1

ncbi gb acc num :

NM_002580.2

uniprot acc num :

Q06141

ncbi mol weight :

19,395 Da

ncbi summary :

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Dec 2010]

uniprot summary :

REG3A: Might be a stress protein involved in the control of bacterial proliferation. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 2p12. Cellular Component: extracellular space; cytoplasm. Molecular Function: carbohydrate binding. Biological Process: heterophilic cell adhesion; cell proliferation; multicellular organismal development; negative regulation of keratinocyte differentiation; acute-phase response

size1 :

0.1 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage