ACSL1 (Acyl-CoA Synthetase Long-chain Family Member 1, Acyl-CoA Synthetase 1, ACS1, FACL1, FACL2, LACS, Long-chain-fatty-acid-CoA Ligase 1, Long-chain Fatty Acid-CoA Ligase 2, Long-chain Acyl-CoA Synthetase 1, LACS 1, LACS1, Long-chain Acyl-CoA Synth | MyBioSource MBS619678 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ACSL1 (Acyl-CoA Synthetase Long-chain Family Member 1, Acyl-CoA Synthetase 1, ACS1, FACL1, FACL2, LACS, Long-chain-fatty-acid-CoA Ligase 1, Long-chain Fatty Acid-CoA Ligase 2, Long-chain Acyl-CoA Synthetase 1, LACS 1, LACS1, Long-chain Acyl-CoA Synth

catalog :

MBS619678

quantity :

0.1 mL

price :

465 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS619678

products type :

Antibody

products full name :

products short name :

ACSL1

products name syn :

Anti -ACSL1 (Acyl-CoA Synthetase Long-chain Family Member 1, Acyl-CoA Synthetase 1, ACS1, FACL1, FACL2, LACS, Long-chain-fatty-acid-CoA Ligase 1, Long-chain Fatty Acid-CoA Ligase 2, Long-chain Acyl-CoA Synthetase 1, LACS 1, LACS1, Long-chain Acyl-CoA Synthetase

other names :

ACSL1 protein; Long-chain-fatty-acid--CoA ligase 1; long-chain-fatty-acid--CoA ligase 1; LACS 1; LACS 2; OTTHUMP00000218456; OTTHUMP00000218457; OTTHUMP00000218460; OTTHUMP00000218461; OTTHUMP00000218462; OTTHUMP00000218465; acyl-CoA synthetase 1; palmitoyl-CoA ligase 1; palmitoyl-CoA ligase 2; paltimoyl-CoA ligase 1; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 1; long-chain acyl-CoA synthetase 2; long-chain fatty acid-CoA ligase 2; long-chain fatty-acid-coenzyme A ligase 1; fatty-acid-Coenzyme A ligase, long-chain 1; fatty-acid-Coenzyme A ligase, long-chain 2; acyl-CoA synthetase long-chain family member 1; Acyl-CoA synthetase 1; ACS1; Long-chain acyl-CoA synthetase 1; LACS 1; Long-chain acyl-CoA synthetase 2; LACS 2; Long-chain fatty acid-CoA ligase 2; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2

other gene names :

ACSL1; ACSL1; ACS1; LACS; FACL1; FACL2; LACS1; LACS2; FACL1; FACL2; LACS; LACS1; LACS2

uniprot entry name :

ACSL1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

specificity :

Recognizes endogenous levels of human total ACSL1 protein. Species Crossreactivity: Mouse and rat.

purity :

Affinity Purified. Purified by peptide affinity chromatography.

form :

Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, 50% glycerol.

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Suitable for use in Western Blot and Immunohistochemistry (Paraffin). Dilution: Western Blot: 1:1000. Immunohistochemistry: 1:25

other info1 :

Immunogen: Synthetic peptide derived from a sequence of human ACSL1.

products categories :

Antibodies; Abs to Enzymes, Synthetase

products description :

Mammalian long-chain acyl-CoA synthetase (ACSL) catalyzes the ligation of the fatty acid to CoA to form fatty acyl-CoA in a two-step reaction (1). Five isoforms of ACSL have been identified (1). These isoforms have different substrate preferences and subcellular localizations (1). Overexpression of ACSL1 results in changes of fatty acid metabolism in rat primary hepatocytes (2).

ncbi gi num :

20072835

uniprot acc num :

P33121

ncbi mol weight :

77,943 Da

ncbi pathways :

Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Fatty Acid Beta Oxidation Pathway (198865); Fatty Acid Biosynthesis Pathway (198873); Fatty Acyl-CoA Biosynthesis Pathway (106115); Fatty Acid Metabolism Pathway (82935); Fatty Acid Metabolism Pathway (296); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Metabolic Pathways (132956); Metabolism Of Lipids And Lipoproteins Pathway (160976)

ncbi summary :

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. [provided by RefSeq]

uniprot summary :

ACSL1: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 6.2.1.3; Ligase; Membrane protein, integral; Lipid Metabolism - fatty acid. Chromosomal Location of Human Ortholog: 4q35.1. Cellular Component: peroxisomal membrane; mitochondrial outer membrane; endoplasmic reticulum membrane; membrane; mitochondrion; plasma membrane; integral to membrane. Molecular Function: ATP binding; long-chain-fatty-acid-CoA ligase activity. Biological Process: response to drug; response to oleate; unsaturated fatty acid metabolic process; lipid biosynthetic process; linoleic acid metabolic process; adiponectin-mediated signaling pathway; triacylglycerol biosynthetic process; cellular lipid metabolic process; long-chain fatty acid metabolic process; response to organic cyclic substance; response to nutrient; xenobiotic catabolic process

size1 :

0.1 mL

price1 :

465 USD

more info or order :

MyBioSource product webpage