FTL (Ferritin, Light Polypeptide, MGC71996, L apoferritin, Ferritin light polypeptide-like 3) | MyBioSource MBS619637 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FTL (Ferritin, Light Polypeptide, MGC71996, L apoferritin, Ferritin light polypeptide-like 3)

catalog :

MBS619637

quantity :

0.1 mg

price :

490 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS619637

products type :

Antibody

products full name :

FTL (Ferritin, Light Polypeptide, MGC71996, L apoferritin, Ferritin light polypeptide-like 3)

products short name :

FTL

products name syn :

Anti -FTL (Ferritin, Light Polypeptide, MGC71996, L apoferritin, Ferritin light polypeptide-like 3)

other names :

ferritin light chain; Ferritin light chain; ferritin light chain; ferritin L-chain; ferritin L subunit; ferritin light polypeptide-like 3; ferritin, light polypeptide

other gene names :

FTL; FTL; NBIA3; MGC71996

uniprot entry name :

FRIL_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Goat

reactivity :

Human

specificity :

Recognizes human FTL. Species Sequence Homology: Mouse, rat, canine, bovine.

purity :

Affinity Purified. Purified by immunoaffinity chromatography.

form :

Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

ELISA (EL/EIA), Western Blot (WB)

app notes :

Suitable for use in ELISA and Western Blot. Dilution: Peptide ELISA: 1:4000. Western Blot: 0.1-0.3ug/ml. Band observed at ~20kD in human brain (Cerebellum), liver and placenta lysates.

other info1 :

Immunogen: Synthetic peptide corresponding to C-GEYLFERLTLKHD from the C-terminus of human FTL (Accession #NP_000137.2).

products categories :

Antibodies; Abs to Serum Proteins

products description :

FTL is the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues.

ncbi gi num :

20149498

ncbi acc num :

NP_000137.2

ncbi gb acc num :

NM_000146.3

uniprot acc num :

P02792

ncbi mol weight :

20,020 Da

ncbi pathways :

Clathrin Derived Vesicle Budding Pathway (119545); Golgi Associated Vesicle Biogenesis Pathway (119546); Membrane Trafficking Pathway (106160); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Porphyrin And Chlorophyll Metabolism Pathway (83021); Porphyrin And Chlorophyll Metabolism Pathway (407); Trans-Golgi Network Vesicle Budding Pathway (106165)

ncbi summary :

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq]

uniprot summary :

FTL: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS). It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3); also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Belongs to the ferritin family. Protein type: Oxidoreductase. Chromosomal Location of Human Ortholog: 19q13.33. Cellular Component: ferritin complex; membrane; cytosol. Molecular Function: identical protein binding; protein binding; ferric iron binding; iron ion binding. Biological Process: receptor-mediated endocytosis; iron ion homeostasis; cellular iron ion homeostasis; post-Golgi vesicle-mediated transport; iron ion transport; transmembrane transport. Disease: Hyperferritinemia With Or Without Cataract; L-ferritin Deficiency; Neurodegeneration With Brain Iron Accumulation 3

size1 :

0.1 mg

price1 :

490 USD

more info or order :

MyBioSource product webpage