antibody

Morphine-6

MBS618188

1 mL

480 USD

polyclonal

goat

nonconjugated

Antibody

Morphine-6

[Morphine-6]

[Anti -Morphine-6]

[mu-type opioid receptor; Mu-type opioid receptor; mu-type opioid receptor; MOP receptor; opioid receptor, mu 1]

[Oprm1; Oprm1; mor; Oprm; muOR; MOP-R; MOR-1; M-OR-1; MOR-1O; Mor; Oprm; M-OR-1; MOR-1]

OPRM_MOUSE

Polyclonal

IgG

Goat

Recognizes Morphine-6: 100%: Crossreactivity: Codeine, 35%; Mor-3-B-D-gluc, 19%: Naloxone, 1%; Methadone, <1%

Serum

Supplied as a liquid.

Store at -20°C. (May be stored at 4°C for short-term only.). Aliquot to avoid repeated freezing and thawing. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Radioimmunoassay (RIA)

Recommended Dilutions: 3H RIA: 1:100,000. Optimal dilutions to be determined by the researcher.

Immunogen: 6-carboxymethyl-Morphine-BSA

Antibodies; Abs to Drugs

89001114

NP_001034741.1

NM_001039652.1

P42866

Class A/1 (Rhodopsin-like Receptors) Pathway (819840); Estrogen Signaling Pathway (799184); Estrogen Signaling Pathway (799197); G Alpha (i) Signalling Events Pathway (819871); G-protein Activation Pathway (819880); GPCR Downstream Signaling Pathway (819869); GPCR Ligand Binding Pathway (819839); GPCRs, Class A Rhodopsin-like Pathway (198308); GPCRs, Other Pathway (198282); Morphine Addiction Pathway (552689)

This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Alternatively spliced transcript variants have been found for this gene, however, many of these variants may be NMD candidates. [provided by RefSeq, Jul 2008]

MOR-1: a Gi-protein-coupled receptor for beta-endorphin, morphine and other opiates. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Ligand-binding inactivates adenylyl cyclase, and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Two splice-variant isoforms have been described. Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR. Cellular Component: dendrite cytoplasm; neuron projection; focal adhesion; integral to plasma membrane; dendrite; integral to membrane; perikaryon; cytosol; lipid raft; membrane; cytoplasm; plasma membrane; sarcolemma. Molecular Function: voltage-gated calcium channel activity; G-protein coupled receptor activity; protein domain specific binding; neuropeptide binding; signal transducer activity; protein binding; opioid receptor activity; G-protein alpha-subunit binding; G-protein beta-subunit binding; beta-endorphin receptor activity; filamin binding. Biological Process: positive regulation of neurogenesis; positive regulation of nitric oxide biosynthetic process; cellular response to stress; negative regulation of nitric oxide biosynthetic process; negative regulation of adenylate cyclase activity; locomotory behavior; behavioral response to ethanol; signal transduction; sensory perception of pain; synaptic transmission; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; response to ethanol; neuropeptide signaling pathway; positive regulation of appetite; reduction of cytosolic calcium ion concentration; opioid receptor, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of excitatory postsynaptic membrane potential; dopamine receptor, adenylate cyclase activating pathway

1 mL

480 USD