Hyaluronic Acid Binding Protein (Hyaluronan Binding Protein, HABP) | MyBioSource MBS617337 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Hyaluronic Acid Binding Protein (Hyaluronan Binding Protein, HABP)

catalog :

MBS617337

quantity :

1 mL

price :

445 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, cow

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

HP = rat hypothalamus HIP2 = rat hippocampus HIP1 = mouse hippocampus.

image 2 :

Same code MBS617337 1:100 Secondary Ab 1:20,000 Exposure 5 min.

image 3 :

Mouse and rat brain sections show a positive signal for HABP that is entirely cytoplasmic. Signal is found in certain brain areas, hippocampus (left) and brain stem (below left).

product information

catalog number :

MBS617337

products type :

Antibody

products full name :

Hyaluronic Acid Binding Protein (Hyaluronan Binding Protein, HABP)

products short name :

[Hyaluronic Acid Binding Protein]

products name syn :

[Anti -Hyaluronic Acid Binding Protein (Hyaluronan Binding Protein, HABP)]

other names :

[hyaluronan-binding protein 2 isoform 2; Hyaluronan-binding protein 2; hyaluronan-binding protein 2; factor VII activating protein; factor VII-activating protease; factor seven-activating protease; hyaluronic acid binding protein 2; plasma hyaluronan binding protein; plasma hyaluronan-binding protein; hepatocyte growth factor activator-like protein; hyaluronan binding protein 2; Factor VII-activating protease; Factor seven-activating protease; FSAP; Hepatocyte growth factor activator-like protein; Plasma hyaluronan-binding protein]

other gene names :

[HABP2; HABP2; FSAP; HABP; PHBP; HGFAL; HGFAL; PHBP; FSAP]

uniprot entry name :

HABP2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Bovine

specificity :

Recognizes Hyaluronic Acid Binding Protein (HABP). Species Crossreactivity: Mouse and rat.

purity :

Serum. Neat serum

form :

Supplied as a liquid, serum, before the addition of glycerol to 40%.

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

app notes :

Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunocytochemistry.

image1 heading :

Testing Data

image2 heading :

Testing Data

image3 heading :

Testing Data

image4 heading :

Testing Data

image4 description :

#3 and #4 from rats brain PFA fixed in situ before brain excision.

image5 heading :

Testing Data

image5 description :

Rat brains were removed unfixed, then post-fixed in 4% PFA. Most HABP labeling was confined in both species to the microvasculature endothelial cells.

other info1 :

Immunogen: Bovine Hyaluronic Acid Binding Protein (HABP)

other info2 :

Similar Product: MBS651823 Hyaluronic Acid Binding Protein (HABP). MBS617337 Hyaluronic Acid Binding Protein (HABP) Pab Rb xBo. MBS651801 Hyaluronic Acid Binding Protein (HABP) (Biotin).

products categories :

Antibodies; Abs to Carbohydrates, Glycoproteins

products description :

Hyaluronan binding protein 1 (HABP1), also known as C1qBP/C1qR and p32, is a ubiquitous acidic glycoprotein that functions in spermatogenesis and as a receptor for proinflammatory molecules (1, 2). HABP1 is synthesized with a 71 amino acid (aa) N-terminal preproprotein and a 208 aa mature region (3). The 3kD mature mouse HABP1, which contains a MAM33-like sequence, shares 90% and 99% aa sequence identity with human and rat HABP1, respectively. HABP1 assembles into a doughnut shaped trimer, with negatively charged residues asymmetrically distributed on one face lining the channel of the complex (4). HABP1 can be cleaved by cell surface MMP-14/MT1-MMP, a protease important in angiogenesis and tumor metastasis (5). Cell surface HABP1 binds a wide range of extracellular molecules, including hyaluronan, vitronectin, complement component C1q, HMW kininogen, and bacterial and viral proteins (2, 6-9). Within the cell, HABP1 binds to molecules containing the C1q globular domain, multiple isoforms of PKC, mitochondrial Hrk, the cytoplasmic tails of adrenergic and GABA-A receptors, the mRNA splicing factor ASF/SF2, and the CBF transcription factor (10-16). Apoptosis and direct phosphorylation by Erk1/2 induces HABP1 translocation to the nucleus (17).

ncbi gi num :

295054188

ncbi acc num :

NP_001171131.1

ncbi gb acc num :

NM_001177660.1

uniprot acc num :

Q14520

ncbi summary :

The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

uniprot summary :

HABP2: Cleaves the alpha-chain at multiple sites and the beta- chain between Lys-53 and Lys-54 but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII. Belongs to the peptidase S1 family. Protein type: Secreted; Motility/polarity/chemotaxis; Protease; Cell adhesion; EC 3.4.21.-; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 10q25.3. Cellular Component: extracellular space; extracellular region. Molecular Function: glycosaminoglycan binding; serine-type endopeptidase activity. Biological Process: proteolysis; cell adhesion. Disease: Thrombophilia Due To Thrombin Defect; Thyroid Cancer, Nonmedullary, 5

size1 :

1 mL

price1 :

445 USD

more info or order :

MyBioSource product webpage