catalog number :
MBS616057
products full name :
S100 Calcium Binding Protein A6 (Calcyclin, Prolactin Receptor Associated Protein)
products short name :
[S100 Calcium Binding Protein A6]
products name syn :
[Anti -S100 Calcium Binding Protein A6 (Calcyclin, Prolactin Receptor Associated Protein)]
other names :
[S100 calcium binding protein A6; Protein S100-A6; protein S100-A6; MLN 4; calcyclin; OTTHUMP00000015472; growth factor-inducible protein 2A9; prolactin receptor-associated protein; S100 calcium-binding protein A6 (calcyclin); S100 calcium binding protein A6; Calcyclin; Growth factor-inducible protein 2A9; MLN 4; Prolactin receptor-associated protein; PRA; S100 calcium-binding protein A6]
other gene names :
[S100A6; S100A6; 2A9; PRA; 5B10; CABP; CACY; CACY]
uniprot entry name :
S10A6_HUMAN
specificity :
Recognizes human S100 Calcium Binding Protein A6.
purity :
Purified by immunoaffinity chromatography
form :
Supplied as a liquid in PBS, pH7.2, 0.02% sodium azide.
storage stability :
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
Recommended Dilution:. Western Blot: 1:500. Optimal dilutions to be determined by the researcher.
image1 heading :
Western Blot (WB)
other info1 :
Grade: Affinity Purified. Immunogen: Synthetic peptide corresponding to aa1-90 of human S100 Calcium Binding Protein A6.
products categories :
Antibodies; Abs to Binding Proteins
products description :
Calcyclin is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.
ncbi acc num :
NP_055439.1
ncbi pathways :
Prostaglandin Synthesis And Regulation Pathway (198912)
ncbi summary :
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq]
uniprot summary :
S100A6: May function as calcium sensor and contribute to cellular calcium signaling (Potential). May function by interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. Belongs to the S-100 family. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: ruffle; extrinsic to internal side of plasma membrane; perinuclear region of cytoplasm; cytoplasm; nuclear envelope; nucleus; cytosol. Molecular Function: protein binding; protein homodimerization activity; zinc ion binding; ion transmembrane transporter activity; calcium ion binding; tropomyosin binding; calcium-dependent protein binding. Biological Process: positive regulation of fibroblast proliferation; axonogenesis; signal transduction