product summary
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company name :
MyBioSource
product type :
antibody
product name :
Neuroglobin
catalog :
MBS614213
quantity :
0.05 mg
price :
550 USD
clonality :
polyclonal
host :
chicken
conjugate :
nonconjugated
reactivity :
human, rat, dog
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS614213
products type :
Antibody
products full name :
Neuroglobin
products short name :
[Neuroglobin]
products name syn :
[Anti -Neuroglobin]
other names :
[neuroglobin; Neuroglobin; neuroglobin; neuroglobin]
other gene names :
[NGB; NGB; NGB]
uniprot entry name :
NGB_HUMAN
clonality :
Polyclonal
isotype :
IgY
host :
Chicken
reactivity :
Canine, Rat
sequence :
MERPEPELIR QSWRAVSRSP LEHGTVLFAR LFALEPDLLP LFQYNCRQFS SPEDCLSSPE FLDHIRKVML VIDAAVTNVE DLSSLEEYLA SLGRKHRAVG VKLSSFSTVG ESLLYMLEKC LGPAFTPATR AAWSQLYGAV VQAMSRGWDG E
specificity :
Recognizes human Neuroglobin at ~17kD.
purity :
Affinity Purified. Purified by immunoaffinity chromatography
form :
Supplied as a lyophilized powder from PBS. Reconstitute with 50ul sterile ddH2O.
concentration :
~1mg/ml (after reconstitution)
storage stability :
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Other applications not tested.
other info1 :
Immunogen: Recombinant protein corresponding to 150aa from human Neuroglobin.
other info2 :
Control No.: C15031782. Revision No.: 061813
products categories :
Antibodies; Abs to Neuroscience
products description :
Neuroglobin, a 151 amino acid reside protein, mainly expressed in vertebrate brain and retina, is a recently identified member of the globin superfamily. Augmenting O2 supply, neuroglobin promotes survival of neurons upon hypoxic injury, potentially limiting brain damage. Moreover, neuroglobin may be a novel oxidative stress-responsive sensor for signal transduction in the brain. Neuroglobin expression is increased by neuronal hypoxia in vitro and focal cerebral ischemia in vivo, and neuronal survival after hypoxia is reduced by inhibiting neuroglobin expression with an antisense oligodeoxynucleotide and enhanced by neuroglobin overexpression.
ncbi gi num :
10864065
ncbi acc num :
NP_067080.1
ncbi gb acc num :
NM_021257.3
uniprot acc num :
Q9NPG2
ncbi mol weight :
16,933 Da
ncbi summary :
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq]
uniprot summary :
NGB: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. Belongs to the globin family. Chromosomal Location of Human Ortholog: 14q24.3. Cellular Component: mitochondrion; perikaryon. Molecular Function: iron ion binding; heme binding; oxygen binding; oxygen transporter activity. Biological Process: oxygen transport; apoptosis
size1 :
0.05 mg
price1 :
550 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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