MyBioSource

antibody

PPARd (Peroxisome Proliferator Activated Receptor, delta)

MBS612577

0.1 mg

635 USD

polyclonal

rabbit

human

western blot, ELISA, enzyme immunoassay

MBS612577

Antibody

PPARd (Peroxisome Proliferator Activated Receptor, delta)

PPARd

Anti -PPARd (Peroxisome Proliferator Activated Receptor, delta)

peroxisome proliferator-activated receptor delta isoform 4; Peroxisome proliferator-activated receptor delta; peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta; OTTHUMP00000016256; OTTHUMP00000016257; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2; peroxisome proliferator-activated receptor beta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; peroxisome proliferator-activated receptor delta; NUCI; Nuclear hormone receptor 1; NUC1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta

PPARD; PPARD; FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB; MGC3931; NR1C2; PPARB

PPARD_HUMAN

Polyclonal

Host: Rabbit; Source: Human

Human

Recognizes the human PPAR delta. Expected to react with mouse and rat based on 100% sequence homology. Crossreactivity with PPAR delta from human, chimpanzee and rabbit may occur as this sequence shows 85% homology with the protein from these sources. No reactivity is expected with other subtypesof PPAR.

Affinity Purified. Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide. No stabilizing proteins added.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot. Dilution: ELISA: 1:2000-1:8000. Western Blot: 1:500-1:2000.

Immunogen: A synthetic peptide, MEQPQEETPEAREE, corresponding to an internal region of mouse PPAR delta.

Antibodies; Abs to Obesity Proteins

Since their discovery in the early 1990's, the peroxisome proliferator activated receptors (PPARs) have attracted significant attention. This is primarily because PPARs serve as receptors for two very important classes of drugs: the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones. Peroxisome proliferators are non-genotoxic carcinogens that are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed PPARs. Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Upon binding fatty acids or hypolipidemic drugs, PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate the expression of target genes. There are 3 known subtypes of PPARs: PPAR-alpha, PPAR-delta and PPAR-gamma. Mostly target genes are involved in the catabolism of fatty acids. Conversely, PPAR-gamma is activated by peroxisome proliferators such as prostaglandins, leukotrienes and antidiabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPARgamma may also be involved in adipocyte differentiation. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 through interaction with specific response elements.

284807159

NP_001165291.1

NM_001171820.1

Q03181

49,903 Da

Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adipogenesis Pathway 198832!!Energy Metabolism Pathway 198907!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!Nuclear Receptor Transcription Pathway 105979!!Nuclear Receptors Pathway 198848!!Nuclear Receptors In Lipid Metabolism And Toxicity Pathway 198887!!PPAR Signaling Pathway 83042

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq]

Function: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Ref.1 Ref.11. Subunit structure: Heterodimer with the retinoid X receptor. Subcellular location: Nucleus. Tissue specificity: Ubiquitous with maximal levels in placenta and skeletal muscle. Sequence similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain.

0.1 mg

635 USD