product summary
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company name :
MyBioSource
product type :
chemical
product name :
Isofagomine D-tartrate
catalog :
MBS6120670
quantity :
5 mg
price :
505 USD
more info or order :
image
image 1 :
Structure of 293800 (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol (2S,3S)-2,3-DihydroxybutanedioateStructure of 015015 (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol (2S,3S)-2,3-Dihydroxybutanedioate; Afegostat
product information
catalog number :
MBS6120670
products type :
Biochemical
products full name :
Isofagomine D-tartrate
products short name :
[Isofagomine D-tartrate]
products name syn :
[(3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol (2S,3S)-2,3-Dihydroxybutanedioate; Afegostat]
host :
Synthetic
storage stability :
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Store under inert atmosphere.
image1 heading :
Structure
other info1 :
CAS Number: 957230-65-8. Molecular Formula: C 10 H 19 NO 9
other info2 :
Appearance: Supplied as a yellow solid. Purity (HPLC): 99.52%. Melting Point: > 64°C. Solubility: Water (Slightly Heated). Method for Determining Identity: Conforms to structure. Atmosphere: Inert gas. TLC Conditions: C18; Methanol: Water: Ammonium Hydroxide = 8: 1: 0.1; Visualized with Ninhydrin and KMnO4; Single spot, Rf = 0.30. Elemental Analysis: Found: %C: 38.14; %H: 6.35; %N: 4.22. Specific Rotation. (c=0.5, Water): -2.8°. Water: ~4%
products description :
Isofagomine (D-tartrate) is a competitive inhibitor of human lysosomal Beta-glucosidase (Ki = 0.016-0.025uM; IC50 = 0.06uM). 1 By interacting with the catalytic pocket of Beta-glucosidase it acts as a chemical chaperone that fibroblasts. 1 increases the amount of Beta-glucosidase by stabilizing and/or promoting the folding of the enzyme. 2 Isofagomine (D-tartrate) has been shown to increase lysosomal Beta-glucosidase activity by 2 to 3-fold in mutant N370S Gaucher. This compound has been studied in the context of Gaucher disease, a lysosomal storage disorder resulting from substantial deficiency of Beta-glucosidase and recently identified as a parkinsonism risk factor.
ncbi mol weight :
297.26
size1 :
5 mg
price1 :
505 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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