product summary
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company name :
MyBioSource
product type :
antibody
product name :
Human Anti-Zika Virus Envelope (EIII Domain) (ZIKV E Protein)
catalog :
MBS6120626
quantity :
0.1 mg
price :
610 USD
clonality :
monoclonal
host :
human
conjugate :
nonconjugated
clone name :
[ZKA64]
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS6120626 image 1
Zika rash: arm.
image 2 :
MyBioSource MBS6120626 image 2
Aedes aegypti Image source: Centers for Disease Control and Prevention Publich Health Image Library.
product information
catalog number :
MBS6120626
products type :
Antibody
products full name :
Human Anti-Zika Virus Envelope (EIII Domain) (ZIKV E Protein)
products short name :
[Zika Virus Envelope]
clonality :
Monoclonal
isotype :
IgG1,k
clone :
[ZKA64]
host :
Human
specificity :
Recognizes and binds specifically to the EDIII domain of the Zika Virus envelope protein (ZIKV E). It does not cross-react with Dengue virus envelope protein (DENV E).
purity :
> = 95% by SDS-PAGE).
form :
Supplied as a liquid in PBS. No preservative added.
concentration :
1mg/ml
storage stability :
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
app notes :
Suitable for use in Neutralization. Other applications not tested. Neutralization: Neutralizes Zika Virus (ZIKV) with an IC50 of ~93ng/ml. Also enhances ZIKV infection in non-permissive K562 cells at a broad range of concentrations (not above 1ug/ml). Optimal dilutions to be determined by the researcher.
image1 heading :
Testing Data
image2 heading :
Testing Data
other info1 :
Endotoxin: <0.001EU/ug. Immunogen: EBV-immortalized memory B cells derived from ZIKV-infected, DENV-naive human donors.
other info2 :
Grade: Purified
products description :
The main route of Zika Virus (ZIKV) infection is through bites by Aedes mosquitos, but the virus may also be sexually and vertically transmitted. Although most of the ZIKV infections are asymptomatic or cause only mild symptoms, there is evidence that ZIKV infection can lead to neurological complications, such as Guillain-Barre syndrome in adults and congenital birth defects, including microcephaly in the developing fetus, likely through its ability to infect human neural progenitor cells. Whereas flavivirus envelope (E) proteins mediate fusion and are the main target of neutralizing antibodies, the non-structural protein 1 (NS1) is secreted by infected cells and is involved in immune evasion and pathogenesis. The E protein contains three domains: EDI involved in the conformational changes required for viral entry; EDII containing the fusion loop; and EDIII which may be involved in binding to cellular receptors. The best specific neutralizing antibodies to ZIKV are directed against the domain EDIII of ZIKV.
products references :
1. Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection: K. Stettler, et al.; Science 353, 823 (2016).
size1 :
0.1 mg
price1 :
610 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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