Noradrenaline (Arterenol) | MyBioSource MBS611744 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Noradrenaline (Arterenol)

catalog :

MBS611744

quantity :

0.1 mg

price :

695 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS611744

products type :

Antibody

products full name :

Noradrenaline (Arterenol)

products short name :

Noradrenaline

products name syn :

Anti -Noradrenaline (Arterenol)

other names :

noradrenaline transporter; Sodium-dependent noradrenaline transporter; sodium-dependent noradrenaline transporter; norepinephrine transporter; neurotransmitter transporter; solute carrier family 6 member 5; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; solute carrier family 6 (neurotransmitter transporter), member 2; Norepinephrine transporter; NET; Solute carrier family 6 member 2

other gene names :

SLC6A2; SLC6A2; NET; NAT1; NET1; SLC6A5; NAT1; NET1; SLC6A5; NET

uniprot entry name :

SC6A2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

specificity :

Using a conjugate Noradrenaline protein carrier (PC), antibody specificity was performed with an ELISA test by competition experiments with the following compounds (1). Compound: 1. Noradrenaline-PC: >1:30. Dopamine-PC: >1:70. Adrenaline-PC: 1:180. L-DOPA-PC: >1:5000. Tyramine-PC: >1:5000. Noradrenaline: >1:5000. (a): Noradrenaline-PC concentration/other conjugated catecholaamines concentration at half displacement.

purity :

Affinity Purified. Antiserum previously preabsobed on protein carriers, and purified by ammonium sulfate precipitation and gel filtration.

form :

Supplied as a lyophilized powder. Reconstitute with 100ul sterile ddH2O

concentration :

~1mg/ml (after reconstitution)

storage stability :

Lyophilized powder may be stored at -20 degree C. Stable for 12 months after receipt at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

tested application :

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC). Other applications not tested.

app notes :

Suitable for use in Western Blot, ELISA, Immunohistochemistry and Immunocytochemistry. Dilution: ELISA, Immunohistochemistry: 1:1000-1:5000. Immunocytochemistry: 1:1000-1:5000. Western Blot: 1:1000-1:2000. Optimal dilutions to be determined by the researcher.

other info1 :

Immunogen: Synthetic Noradrenaline conjugated to protein carrier.

products categories :

Antibodies; Abs to Hormones, Steroids

ncbi gi num :

189258

ncbi acc num :

AAA59943.1

uniprot acc num :

P23975

ncbi pathways :

Monoamine Transport Pathway (198851); Na+/Cl- Dependent Neurotransmitter Transporters Pathway (161070); SLC-mediated Transmembrane Transport Pathway (119558); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (119571)

ncbi summary :

This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

uniprot summary :

SLC6A2: Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. Defects in SLC6A2 are a cause of orthostatic intolerance (OI). OI is a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily. Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral. Chromosomal Location of Human Ortholog: 16q12.2. Cellular Component: neuron projection; cell surface; membrane; integral to plasma membrane; plasma membrane; lipid raft. Molecular Function: protein binding; beta-tubulin binding; monoamine transmembrane transporter activity; alpha-tubulin binding; norephinephrine:sodium symporter activity. Biological Process: response to drug; synaptic transmission; norepinephrine transport; transport; neurotransmitter transport; monoamine transport; response to pain; transmembrane transport. Disease: Orthostatic Intolerance

size1 :

0.1 mg

price1 :

695 USD

more info or order :

MyBioSource product webpage