Azurocidin, Human (CAP37, HBP) | MyBioSource MBS611657 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Azurocidin, Human (CAP37, HBP)

catalog :

MBS611657

quantity :

1 mL

price :

420 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS611657

products type :

Antibody

products full name :

Azurocidin, Human (CAP37, HBP)

products short name :

[Azurocidin]

products name syn :

[Anti -Azurocidin, Human (CAP37, HBP)]

other names :

[azurocidin preproprotein; Azurocidin; azurocidin; neutrophil azurocidin; heparin-binding protein; cationic antimicrobial protein 37; cationic antimicrobial protein CAP37; azurocidin 1; Cationic antimicrobial protein CAP37; Heparin-binding protein]

other gene names :

[AZU1; AZU1; AZU; HBP; NAZC; AZAMP; CAP37; HUMAZUR]

uniprot entry name :

CAP7_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence positions :

[27-248]

sequence length :

248

specificity :

Recognizes human neutrophil azurocidin. Single arc detected on Immunoelectrophoresis of human neutrophil granule extract.

purity :

Purified by ammonium sulfate precipitation.

form :

Supplied as a liquid in PBS, pH 7.5, 0.05% sodium azide.

concentration :

19.4 mg/ml

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

ELISA (EL/EIA), Western Blot (WB), Immunoelectrophoresis. Other applications not tested.

app notes :

Indirect ELISA: >1:4000. Western Blot: 1:2000 reacts with 0.3ug and 0.6ug of antigen. Optimal dilutions to be determined by the researcher.

other info1 :

Immunogen: Human neutrophil azurocidin.Swiss/Uniprot

other info2 :

Grade: Purified

products categories :

Antibodies; Abs to Enzymes

products description :

Human Azurocidin, a 29kD polypeptides member of a family of serine protease homologs stored in azurophil granules, may play a role in inflammatory and antimicrobial processes involving PMN. Azurocidin (CAP37, HBP) is an antimicrobial and chemotactic protein that is part of the innate defenses of human neutrophils. In addition, azurocidin is an inactive serine protease homolog with binding sites for diverse ligands including heparin and the bovine pancreatic trypsin inhibitor (BPTI). The structure of the protein reveals a highly cationic domain concentrated on one side of the molecule and responsible for its strong polarity.

ncbi gi num :

11342670

ncbi acc num :

NP_001691.1

ncbi gb acc num :

NM_001700.3

uniprot acc num :

P20160

ncbi summary :

Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. The protein encoded by this gene is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq]

uniprot summary :

AZU1: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G. Belongs to the peptidase S1 family. Elastase subfamily. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: azurophil granule; extracellular region. Molecular Function: heparin binding; toxin binding; serine-type endopeptidase activity. Biological Process: positive regulation of tumor necrosis factor biosynthetic process; positive regulation of cell adhesion; microglial cell activation; glial cell migration; defense response to Gram-negative bacterium; proteolysis; macrophage chemotaxis; induction of positive chemotaxis; monocyte activation; cellular extravasation; positive regulation of phagocytosis; positive regulation of MHC class II biosynthetic process; positive regulation of fractalkine biosynthetic process; protein kinase C activation; positive regulation of interleukin-1 beta biosynthetic process; immune response; protein processing; regulation of vascular permeability; inflammatory response; negative regulation of apoptosis

size1 :

1 mL

price1 :

420 USD

more info or order :

MyBioSource product webpage