Musashi-1 RNA Binding Protein (Musashi 1, Musashi1, Msi1, Msi-1, Musashi Homolog 1, RNA Binding Protein Musashi Homolog 1) | MyBioSource MBS611647 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Musashi-1 RNA Binding Protein (Musashi 1, Musashi1, Msi1, Msi-1, Musashi Homolog 1, RNA Binding Protein Musashi Homolog 1)

catalog :

MBS611647

quantity :

0.1 mg

price :

580 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

more info or order :

MyBioSource product webpage

image

image 1 :

Image of staining with MBS611647 (1:100) shows Musashi (green) staining on neural rosettes (human). Nuclei are counterstained blue (DAPI). Cells were fixed with 4% PFA. No antigen retrieval was done.

image 2 :

Musashi-positive cells stained with MBS611647 (1:150) in the ventricular zone of E14.5 mouse medulla. Image taken at 200x magnification. The sections were 4% PFA fixed, paraffin-embedded and cut at 5 micron

image 3 :

Western Blot analysis of Musashi-1 with MBS611647 (1:500). 10ug of rat neural stem cell lysate (lane 1) and normal human brain lysate (lane 2)

product information

catalog number :

MBS611647

products type :

Antibody

products full name :

Musashi-1 RNA Binding Protein (Musashi 1, Musashi1, Msi1, Msi-1, Musashi Homolog 1, RNA Binding Protein Musashi Homolog 1)

products short name :

[Musashi-1 RNA Binding Protein]

products name syn :

[Anti -Musashi-1 RNA Binding Protein (Musashi 1, Musashi1, Msi1, Msi-1, Musashi Homolog 1, RNA Binding Protein Musashi Homolog 1)]

other names :

[Musashi; RNA-binding protein Musashi homolog 1; RNA-binding protein Musashi homolog 1; musashi1; musashi-1; musashi RNA-binding protein 1]

other gene names :

[MSI1; MSI1; Musashi-1]

uniprot entry name :

MSI1H_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat. Species Crossreactivity: rat and mouse.

specificity :

Recognizes human Musashi-1 RNA binding protein.

purity :

Affinity Purified. Purified by Immunoaffinity chromatography.

form :

Supplied as a liquid in PBS, 0.02% sodium azide.

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

Western Blot (WB), Immunohistochemistry (IHC-F/P), Immunocytochemistry (ICC)

app notes :

Suitable for use in:. Western Blot: 1:500. Immunocytochemistry (Frozen/Paraffin): 1:10-1:2000

image1 heading :

Testing Data

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Western Blot (WB)

other info1 :

Immunogen: Synthetic peptide corresponding to aa5-21, APQPGLASPDSPHDPCK of human Musashi-1 binding protein.

products categories :

Antibodies; Abs to Binding Proteins

products description :

Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi-1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia. It may play a role in the pathogenesis of various neurodegenerative disorders. Musashi1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play be a vital role in the development of several types of carcinoma such as human heptoma, and may be a useful molecular marker for tumor detection.

ncbi gi num :

3786320

ncbi acc num :

BAA33962.1

uniprot acc num :

O43347

ncbi mol weight :

39,125 Da

ncbi pathways :

MRNA Surveillance Pathway (193328); MRNA Surveillance Pathway (193184)

ncbi summary :

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]

uniprot summary :

Musashi-1: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5 - GUUAGUUAGUUAGUU-3 and other sequences containing the pattern 5 - [GA]U(1-3)AGU-3 . May play a role in the proliferation and maintenance of stem cells in the central nervous system. Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines. Belongs to the Musashi family. Protein type: RNA-binding. Chromosomal Location of Human Ortholog: 12q24. Cellular Component: polysome; cytoplasm; nucleus. Molecular Function: RNA binding; nucleotide binding; poly(U) binding. Biological Process: nervous system development; epithelial cell differentiation; response to hormone stimulus

size1 :

0.1 mg

price1 :

580 USD

more info or order :

MyBioSource product webpage