PPARd, CT (Peroxisome Proliferator Activated Receptor, delta) | MyBioSource MBS610817 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

PPARd, CT (Peroxisome Proliferator Activated Receptor, delta)

catalog :

MBS610817

quantity :

0.1 mg

price :

615 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS610817

products type :

Antibody

products full name :

PPARd, CT (Peroxisome Proliferator Activated Receptor, delta)

products short name :

PPARd

products name syn :

Anti -PPARd, CT (Peroxisome Proliferator Activated Receptor, delta)

other names :

peroxisome proliferator-activated receptor delta isoform 4; Peroxisome proliferator-activated receptor delta; peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta; OTTHUMP00000016256; OTTHUMP00000016257; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2; peroxisome proliferator-activated receptor beta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; peroxisome proliferator-activated receptor delta; NUCI; Nuclear hormone receptor 1; NUC1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta

other gene names :

PPARD; PPARD; FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB; MGC3931; NR1C2; PPARB

uniprot entry name :

PPARD_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Host: Goat; Source: Human

reactivity :

Human

specificity :

Recognizes an epitope within the C-terminal (CT) region of isoform 1 of human PPARd.

purity :

Affinity Purified. Purified by affinity chromatography.

form :

Supplied as a TBS, 0.5% BSA, 0.02% sodium azide.

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

ELISA (EL/EIA), Western Blot (WB)

app notes :

Suitable for use in ELISA and Western Blot. Dilution: ELISA: 1:16,000. Western Blot: 0.3-1ug/ml. Detects a band of ~50kD in Jurkat T cell lysates.

other info1 :

Immunogen: Peptide corresponding to CHPLLQEIYKDMY from the C-Terminal region of PPARd (NP_006229.1). Species Sequence Homology: mouse, rat, porcine, chicken

products categories :

Antibodies; Abs to Obesity Proteins

products description :

PPARd (Peroxisome Proliferator Activated Receptor, delta) is a ubiquitously expressed member of the nuclear hormone receptor subfamily of transcription factors, which regulates peroxisome numbers and influences fatty acid metabolism. The transcriptional activity of PPAR delta depends upon its interaction with retinoid X receptor (RXR), which together bind to peroxisome proliferator-response elements (PPREs) within the promoter region of target genes, in the presence of cofactors. The interaction of PPAR delta with NCoR (nuclear receptor corepressor) and SMRT (silencing mediator for retinoid and thyroid hormone receptor), results in repression of PPAR delta transactivation.

ncbi gi num :

284807159

ncbi acc num :

NP_001165291.1

ncbi gb acc num :

NM_001171820.1

uniprot acc num :

Q03181

ncbi mol weight :

49,903 Da

ncbi pathways :

Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adipogenesis Pathway 198832!!Energy Metabolism Pathway 198907!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!Nuclear Receptor Transcription Pathway 105979!!Nuclear Receptors Pathway 198848!!Nuclear Receptors In Lipid Metabolism And Toxicity Pathway 198887!!PPAR Signaling Pathway 83042

ncbi summary :

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq]

uniprot summary :

Function: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Ref.1 Ref.11. Subunit structure: Heterodimer with the retinoid X receptor. Subcellular location: Nucleus. Tissue specificity: Ubiquitous with maximal levels in placenta and skeletal muscle. Sequence similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain.

size :

0.1 mg

price :

615 USD