catalog number :
MBS6101688
products type :
Biochemical
products full name :
Benzo[a]pyrene Diol Epoxide (BPDE)
products short name :
[Benzo[a]pyrene Diol Epoxide]
products name syn :
[(7R,8S,8aS,9aR)-rel-7,8,8a,9a-Tetrahydrobenzo[10,11]chryseno[3,4-b]oxirene-7,8-diol; (7 alpha,8 beta,8a alpha,9a alpha)-7,8,8a,9a-Tetrahydrobenzo[10,11]chryseno[3,4-b]oxirene-7,8-diol; (+/-)-7 alpha,8beta-Dihydroxy-9 beta,10 beta -epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; (+/-)-7 beta,8alpha-Dihydroxy-9 alpha,10 alpha -epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; (+/-)-anti-BPDE; anti-Benzo[a]pyrene-7,8-diol-9,10-epoxide; trans-7,8-Dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene]
storage stability :
May be stored at RT for short term only. Long-term storage is recommended at -20 degree C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Store under inert atmosphere. Light sensitive.
image1 heading :
Structure
other info1 :
CAS Number: 58917-67-2. Molecular Formula: C20H14O3. Source: Synthetic. Appearance: Supplied as a yellow solid. Melting Point: 164-166 degree C. Solubility: DMSO(Slightly). Method for Determining Identity: Proton NMR (DMSO-d 6 ) Spectroscopic and Mass Spectometric Analysis. TLC Conditions: SiO2; Tetrahydrofuran: Ammonium Hydroxide = 9.5:0.5; Visualized with UV and AMCS; Single spot, Rf= 0.50. Elemental Analysis: Calculated: %C:79.56, %H: 4.67. Found: %C: 77.59, %H: 4.68. Atmosphere: Inert gas
products categories :
Biochemicals; Biochem-Mutagenesis
products description :
Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway. Benzo [a]pyrene diol epoxide (BPDE), a carcinogen present in tobacco smoke as well as in environmental pollution, induces esophageal carcinogenesis.