Adenosine Receptor A2A | MyBioSource MBS609984 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Adenosine Receptor A2A

catalog :

MBS609984

quantity :

0.2 mg

price :

610 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5H30

reactivity :

human, mouse, rat, dog

application :

western blot, immunohistochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS609984

products type :

Antibody

products full name :

Adenosine Receptor A2A

products short name :

Adenosine Receptor A2A

products name syn :

Anti -Adenosine Receptor A2A

other names :

adenosine receptor A2a; Adenosine receptor A2a; adenosine receptor A2a; OTTHUMP00000198454; adenosine A2 receptor; adenosine receptor subtype A2a; adenosine A2a receptor

other gene names :

ADORA2A; ADORA2A; RDC8; hA2aR; ADORA2; ADORA2

uniprot entry name :

AA2AR_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

5H30

host :

Mouse

reactivity :

Canine, Guinea Pig, Human, Mouse, Rabbit, Rat

specificity :

Recognizes human adenosine receptor A2A at ~43kD.

purity :

Affinity Purified. Purified by Protein G affinity chromatography.

form :

Supplied as a liquid in 0.01M sodium phosphate, pH 7.0, 0.15M sodium chloride, 0.01M EDTA.

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

app notes :

Suitable for use in Western Blot, Immunohistochemistry and Flow Cytometry. Dilution: Western Blot: 1:1000-1:5000. Detects Adenosine Receptor A2A in HEK293 cells expressing canine A1/A2A receptor chimeras. Immunohistochemistry: 1ug/ml. Detects Adenosine Receptor A2A in paraformaldehyde-fixed mouse brain striatal sections. Not detected in Adenosine Receptor A2A knockout mice. Flow Cytometry: Detects Adenosine Receptor A2A in transfected HEK293 cells.

other info1 :

Immunogen: 6His-tagged full-length human recombinant A2A receptor. Epitope: third intracellular loop (SQPLPGER).

other info2 :

Positive Control: Mouse brain striatal sections

products categories :

Antibodies; Abs to Receptors

products description :

Adenosine receptors, a class of purinergic G-protein coupled receptors with adenosine as endogenous ligands mediate several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission. The activity of A2A adenosine receptor is mediated by G proteins which activate adenylyl cyclase. It is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB and may suggest a new strategy for using this mechanism in neurodegenerative diseases.

ncbi gi num :

5921992

ncbi acc num :

NP_000666.2

ncbi gb acc num :

NM_000675.4

uniprot acc num :

P29274

ncbi mol weight :

44,707 Da

ncbi pathways :

Activation Of TRKA Receptors Pathway (106456); Adenosine P1 Receptors Pathway (106375); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); GPCRs, Other Pathway (198765)

ncbi summary :

This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. [provided by RefSeq]

uniprot summary :

ADORA2A: one of several receptor subtypes for adenosine. A G-protein coupled receptor. Activation is mediated by G proteins which activate adenylyl cyclase. Abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 22q11.23. Cellular Component: membrane; integral to plasma membrane; plasma membrane. Molecular Function: identical protein binding; protein binding; enzyme binding; adenosine receptor activity, G-protein coupled. Biological Process: central nervous system development; nerve growth factor receptor signaling pathway; blood circulation; apoptosis; adenylate cyclase activation; phagocytosis; G-protein signaling, coupled to cAMP nucleotide second messenger; cell-cell signaling; sensory perception; cellular defense response; cAMP biosynthetic process; inflammatory response; blood coagulation; adenosine receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway

size1 :

0.2 mg

price1 :

610 USD

more info or order :

MyBioSource product webpage