antibody

c-myc, Epitope Tag (Myc, myc-1, Cellular Myelocytomatosis Oncogene, Myc2, Niard, Nird, Transcription Factor p64, v-myc Avian Myelocytomatosis Viral Oncogene Homolog)

MBS609973

0.05 mL

365 USD

monoclonal

mouse

nonconjugated

[10K114]

western blot, ELISA, immunocytochemistry, immunoprecipitation, enzyme immunoassay

Antibody

c-myc, Epitope Tag (Myc, myc-1, Cellular Myelocytomatosis Oncogene, Myc2, Niard, Nird, Transcription Factor p64, v-myc Avian Myelocytomatosis Viral Oncogene Homolog)

[c-myc, Epitope Tag]

[Anti -c-myc, Epitope Tag (Myc, myc-1, Cellular Myelocytomatosis Oncogene, Myc2, Niard, Nird, Transcription Factor p64, v-myc Avian Myelocytomatosis Viral Oncogene Homolog)]

[c-myc; C-myc protein; myc proto-oncogene protein; OTTHUMP00000158589; OTTHUMP00000227763; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc avian myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor; v-myc myelocytomatosis viral oncogene homolog (avian)]

[MYC; c-myc; MRTL; c-Myc; bHLHe39]

Q6LBK7_HUMAN

Monoclonal

IgG1

[10K114]

Mouse

Human

Recognizes over-expressed or recombinant proteins containing the Myc epitope tag. Species Crossreactivity: human.

Ascites. Ascites

Supplied as a liquid.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunofuorescence. Dilution: ELISA: 1:2000. Western Blot: 1:5000. Immunofluorescence: 1:2000. Immunoprecipitation: 1:200

Immunogen: Synthetic peptide corresponding to aa410-419, EQKLISEEDL, of human c-Myc, conjugated to KLH.

Antibodies; Abs to Cancer Markers

The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.

396512

Q6LBK7

7,012 Da

Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Apoptosis Pathway (198797); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); C-MYB Transcription Factor Network Pathway (138073); C-MYC Pathway (169344); CD40/CD40L Signaling Pathway (138061); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (83054)

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq]

Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes. Protein type: Transcription factor; Oncoprotein; Nucleolus; DNA-binding. Chromosomal Location of Human Ortholog: 8q24.21. Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus; cytosol. Molecular Function: protein dimerization activity; protein binding; DNA binding; protein complex binding; transcription factor binding; transcription factor activity. Biological Process: cellular iron ion homeostasis; oxygen transport; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; chromosome organization and biogenesis; positive regulation of fibroblast proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; response to gamma radiation; cell cycle arrest; response to drug; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; regulation of telomere maintenance; MAPKKK cascade; negative regulation of cell division; negative regulation of stress-activated MAPK cascade; negative regulation of monocyte differentiation; chromatin remodeling; ureteric bud branching; regulation of gene expression; negative regulation of fibroblast proliferation; energy reserve metabolic process; positive regulation of transcription from RNA polymerase II promoter; gene expression; response to DNA damage stimulus; positive regulation of epithelial cell proliferation; negative regulation of apoptosis. Disease: Burkitt Lymphoma

0.05 mL

365 USD