Asialoglycoprotein Receptor (ASGPR) | MyBioSource MBS609338 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Asialoglycoprotein Receptor (ASGPR)

catalog :

MBS609338

quantity :

0.1 mg

price :

1030 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[8D7]

reactivity :

human, rat

application :

enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS609338

products type :

Antibody

products full name :

Asialoglycoprotein Receptor (ASGPR)

products short name :

[Asialoglycoprotein Receptor]

products name syn :

[Mouse anti-Rat Asialoglycoprotein Receptor (ASGPR)]

other names :

[asialoglycoprotein receptor 2 isoform c; Asialoglycoprotein receptor 2; asialoglycoprotein receptor 2; hepatic lectin H2; HBxAg-binding protein; C-type lectin domain family 4 member H2; asialoglycoprotein receptor 2; C-type lectin domain family 4 member H2; Hepatic lectin H2]

other gene names :

[ASGR2; ASGR2; HL-2; HBXBP; ASGPR2; ASGP-R2; CLEC4H2; CLEC4H2; ASGP-R 2; ASGPR 2; HL-2]

uniprot entry name :

ASGR2_HUMAN

clonality :

Monoclonal

clone :

[8D7]

host :

Mouse

reactivity :

Human, Rat

specificity :

Recognizes the rat Asialoglycoprotein Receptor at ~42kD. Species Crossreactivity: Human

purity :

Purified by Protein G affinity chromatography.

form :

Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.

concentration :

0.1 mg/ml

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). other applications have not been tested

app notes :

Recommended Dilution:. Flow Cytometry: 1:10. Western Blot: 1:10 using non-reducing conditions. Immunohistochemistry (frozen): 1:10. Optimal dilutions to be determined by the researcher

other info1 :

Immunogen: Rat Asialoglycoprotein Receptor

products categories :

Antibodies; Abs to Receptors

products description :

The asialoglycoprotein receptor (ASGPR) is a transmembrane glycoprotein (42kD) which mediates binding, internalisation and degradation of extracellular glycoproteins that have exposed terminal galactose residues. The receptor is expressed on the surface of the hepatocytes in a polar manner, i.e. it is present on the sinusoidal and lateral plasma membranes but not on the bile canalicular membrane. The mammalian hepatic ASGPR mediates the endocytosis and degradation of serum proteins from which terminal sialic residues have been removed.

ncbi gi num :

18426877

ncbi acc num :

NP_550436.1

ncbi gb acc num :

NM_080914.2

uniprot acc num :

P07307

ncbi mol weight :

35,092 Da

ncbi pathways :

Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541)

ncbi summary :

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

uniprot summary :

ASGP-R: cell surface receptor that mediates the endocytosis of plasma glycoproteins in which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. It transports these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates. Then the receptor is recycled back to the cell surface. There are four alternatively spliced transcript variants of this gene. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 17p. Cellular Component: integral to membrane. Molecular Function: protein binding; asialoglycoprotein receptor activity; carbohydrate binding. Biological Process: receptor-mediated endocytosis; cell surface receptor linked signal transduction; glycoprotein metabolic process; lipid homeostasis; regulation of protein stability; bone mineralization

size1 :

0.1 mg

price1 :

1030 USD

more info or order :

MyBioSource product webpage