other

AMPK Inhibitor, Compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, BMP Inhibitor I)

MBS6092861

1 mg

320 USD

Biochemical

AMPK Inhibitor, Compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, BMP Inhibitor I)

AMPK Inhibitor, Compound C

98%

Supplied as a light yellow solid.

May be stored at 4 degree C. For long-term storage, aliquot and store at 4 degree C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. This product is sensitive to light.

CAS Number: 866405-64-3. Molecular Formula: C24H25N5O

Solubility: DMSO (4 mg/ml), 2% HCl (10 mg/ml), 2% Acetic Acid (10 mg/ml), or Methanol (3 mg/ml)

Biochemicals; Biochem-Inhibitors

A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50=25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFbR-I, ZAPK, Syk, PKCth, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100=2.5uM) and VEGF signaling-dependent intersomitic vessel formation (EC50=5uM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR and/or Metformin for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Also available as a 10mM solution in DMSO.

399.5

1 mg

320 USD

5 mg

505

10 mg

625