antibody

FOLR2 (Folate Receptor beta, FR-beta, Folate Receptor 2 Folate Receptor, Fetal/Placental Placental Folate-binding Protein, FBP)

MBS609209

0.1 mg

505 USD

monoclonal

mouse

nonconjugated

4B12

western blot, ELISA, enzyme immunoassay

Antibody

FOLR2 (Folate Receptor beta, FR-beta, Folate Receptor 2 Folate Receptor, Fetal/Placental Placental Folate-binding Protein, FBP)

FOLR2

Anti -FOLR2 (Folate Receptor beta, FR-beta, Folate Receptor 2 Folate Receptor, Fetal/Placental Placental Folate-binding Protein, FBP)

folate receptor beta; Folate receptor beta; folate receptor beta; folate receptor, beta; folate receptor, fetal/placental; placental folate-binding protein; folate-binding protein, fetal/placental; folate receptor 2 (fetal); Folate receptor 2; Folate receptor, fetal/placental; Placental folate-binding protein

FOLR2; FOLR2; FBP; FR-P3; FR-BETA; BETA-HFR; FBP/PL-1; FR-beta; FBP

FOLR2_HUMAN

Monoclonal

IgG2a

4B12

Host: Mouse; Source: Human

Human

HHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTSR
LYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQ
VNQTWRKERFLDVPL*

Recognizes human FOLR2.

Purified. Purified

Supplied as a liquid in PBS, pH 7.2.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot. Dilution: Sandwich ELISA: 1-5ug/ml using recombinant protein. The detetion limit for recombinant GST tagged FOLR2 is ~1ng/ml. Western Blot: 1-5ug/ml. Detects a band at ~36.34kD using immunogen protein lysate.

Immunogen: Partial recombinant protein corresponding to aa 36-129 from FOLR2 (NP_000794) with GST tag. MW of the GST tag alone is 26kD.

Antibodies; Abs to Receptors

The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.

166064054

NP_001107007.1

NM_001113535.1

P14207

29,280 Da

Endocytosis Pathway 102279!!Endocytosis Pathway 102181

The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Subcellular location: Cell membrane; Lipid-anchor GPI-anchor. Secreted . Probable Ref.5. Tissue specificity: Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. Post-translational modification: N-glycosylated. Sequence similarities: Belongs to the folate receptor family.

0.1 mg

505 USD