antibody

Ribonuclease inhibitor 1 (RNH1)

MBS608354

0.1 mL

490 USD

monoclonal

mouse

nonconjugated

[10C309]

human, mouse

western blot, ELISA, enzyme immunoassay

Antibody

Ribonuclease inhibitor 1 (RNH1)

[Ribonuclease inhibitor 1]

[Anti -Ribonuclease inhibitor 1 (RNH1)]

[ribonuclease inhibitor; Ribonuclease inhibitor; ribonuclease inhibitor; OTTHUMP00000147628; OTTHUMP00000229864; OTTHUMP00000229865; OTTHUMP00000229866; OTTHUMP00000229870; OTTHUMP00000229871; OTTHUMP00000229872; placental RNase inhibitor; Placental ribonuclease inhibitor; ribonuclease/angiogenin inhibitor 1; Placental ribonuclease inhibitor; Placental RNase inhibitor; Ribonuclease/angiogenin inhibitor 1]

[RNH1; RNH1; RAI; RNH; MGC4569; MGC18200; MGC54054; PRI; RNH]

RINI_HUMAN

Monoclonal

IgG2a,k

[10C309]

Mouse

Recognizes human RNH1. Species Crossreactivity: Mouse

Recognizes human RNH!. Species Crossreactivity: Mouse

Affinity Purified. Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

1mg/ml

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.:. Dilution:. ELISA: 1:1000. Western Blot: 1:1000-2000. Optimal dilutions to be determined by the researcher.

Testing Data

Immunogen: Recombinant protein corresponding to aa7-461 from human RNH1 expressed i el. coli.

Antibodies; Abs to Enzymes, Ribonuclease

Ribonuclease inhibitor 1(RNH1) the placental ribonuclease inhibitor, is an acid protein with a molecular weight of 50kD. RNH1 is a member of a family of proteinaceous cytoplasmic RNase inhibitors that are expressed in many tissues and bind to both intracellular and extracellular RNases in the cytosol. RNH1 is a role in abolishing the ribonucleolytic and angiogenic activities of angiogenin.

42822874

NP_976319.1

NM_203385.1

P13489

49,973 Da

Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM]

RNH1: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. Protein type: Inhibitor. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: angiogenin-PRI complex; cytoplasm. Molecular Function: protein binding; ribonuclease inhibitor activity. Biological Process: negative regulation of catalytic activity; mRNA catabolic process; regulation of angiogenesis

0.1 mL

490 USD