TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2, Estrogen Responsive Element Associated Gene 1, Estrogen-responsive Element-associated Gene 1 Protein, EREG1, KNP3, Long Transient Receptor Potential Channel 2, LTRPC 2, LTRPC2, | MyBioSource MBS608280 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2, Estrogen Responsive Element Associated Gene 1, Estrogen-responsive Element-associated Gene 1 Protein, EREG1, KNP3, Long Transient Receptor Potential Channel 2, LTRPC 2, LTRPC2,

catalog :

MBS608280

quantity :

0.1 mg

price :

580 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[10F775]

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS608280

products type :

Antibody

products full name :

products short name :

[TRPM2]

products name syn :

[Anti -TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2, Estrogen Responsive Element Associated Gene 1, Estrogen-responsive Element-associated Gene 1 Protein, EREG1, KNP3, Long Transient Receptor Potential Channel 2, LTRPC 2, LTRPC2, LTRPC]

other names :

[transient receptor potential cation channel subfamily M member 2; Transient receptor potential cation channel subfamily M member 2; transient receptor potential cation channel subfamily M member 2; LTrpC-2; OTTHUMP00000038504; OTTHUMP00000038505; OTTHUMP00000109530; OTTHUMP00000207883; transient receptor potential channel 7; long transient receptor potential channel 2; estrogen-responsive element-associated gene 1 protein; transient receptor potential cation channel, subfamily M, member 2; Estrogen-responsive element-associated gene 1 protein; Long transient receptor potential channel 2; LTrpC-2; LTrpC2; Transient receptor potential channel 7]

other gene names :

[TRPM2; TRPM2; KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; NUDT9L1; MGC133383; EREG1; KNP3; LTRPC2; TRPC7]

uniprot entry name :

TRPM2_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

[10F775]

host :

Mouse

reactivity :

Human

specificity :

Recognizes human TrpC7. Species Crossreactivity: Mouse and Rat.

purity :

Purified by Protein G affinity chromatography.

form :

Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide, 50% glycerol.

concentration :

1 mg/ml

storage stability :

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC). Other applications not yet tested.

app notes :

Recommended Dilution:. Western Blot: 1:1000. 1ug/ml detects TrpC7 in 10ug of rat brain lyste using goat anti-mouse IgG (HRP) as secondary antibody. Immunohistochemistry: 1:1000. Immunofluorescence: 1:100. Optimal dilutions to be determined by the researcher.

other info1 :

Immunogen: Synthetic peptide corresponding to aa 845-862 of human TRPC7. Cellular Location: membrane. Grade: Affinity Purified

products categories :

Antibodies; Abs to Receptors, Estrogen

products description :

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical force.

ncbi gi num :

4507689

ncbi acc num :

NP_003298.1

ncbi gb acc num :

NM_003307.3

uniprot acc num :

Q9HCX4

ncbi summary :

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq]

uniprot summary :

TRPM2: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.6.1.13; Membrane protein, multi-pass; Membrane protein, integral; Hydrolase; Transporter; Channel, calcium. Chromosomal Location of Human Ortholog: 21q22.3. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: ADP-ribose diphosphatase activity; calcium channel activity; manganese ion transmembrane transporter activity; sodium channel activity. Biological Process: response to hydroperoxide; metabolic process; calcium ion transport; transmembrane transport

size1 :

0.1 mg

price1 :

580 USD

more info or order :

MyBioSource product webpage