GluR2,4 (Glutamate Receptor) | MyBioSource MBS606294 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GluR2,4 (Glutamate Receptor)

catalog :

MBS606294

quantity :

0.1 mg

price :

690 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[2Q58]

reactivity :

human, rat

application :

enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Staining of adult monkey pryamidal cells using MBS606294.

product information

catalog number :

MBS606294

products type :

Antibody

products full name :

GluR2,4 (Glutamate Receptor)

products short name :

[GluR2,4]

products name syn :

[Anti -GluR2,4 (Glutamate Receptor)]

other names :

[glutamate receptor 2 isoform 1; Glutamate receptor 2; glutamate receptor 2; gluR-2; gluR-B; OTTHUMP00000165322; OTTHUMP00000165323; OTTHUMP00000165324; OTTHUMP00000220942; OTTHUMP00000220943; AMPA-selective glutamate receptor 2; glutamate receptor, ionotropic, AMPA 2; AMPA-selective glutamate receptor 2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2]

other gene names :

[GRIA2; GRIA2; GLUR2; GLURB; GluA2; HBGR2; GluR-K2; GLUR2]

uniprot entry name :

GRIA2_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

[2Q58]

host :

Mouse

reactivity :

Human, Monkey, Rat

specificity :

Recognizes human Glutamate Receptor 2 (GluR2) by RIA and Western Blot. Recognizes both GluR2 and GluR4 in Immunohistochemistry and Immunoprecipitation. Species crossreactivity: monkey and rat.

purity :

Purified

form :

Supplied as a liquid in PBS. Preservative free.

concentration :

7.8 mg/mL

storage stability :

May be stored at 4° for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

tested application :

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Radioimmunoassay (RIA), Immunoprecipitation (IP) . Other applications not tested.

app notes :

Immunohistochemistry: 1:500-1:1000 on 4% paraformaldehyde fixed tissue. Optimal dilutions to be determined by the researcher.

image1 heading :

Testing Data

other info1 :

Immunogen: Recombinant fusion protein TrpE-GluR2

products categories :

Antibodies; Abs to Receptors

products description :

Glutamate receptors are the major excitatory neurotransmitter receptors in the central nervous system (CNS). They play critical roles in the mechanisms of synaptic plasticity and in the development of the nervous system. In addition, these receptors may be involved in the neuronal cell death that occurs in several neuropathological conditions.

ncbi gi num :

74275354

ncbi acc num :

NP_000817.2

ncbi gb acc num :

NM_000826.3

uniprot acc num :

P42262

ncbi pathways :

Activation Of AMPA Receptors Pathway (106539); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway (106536); Glutamatergic Synapse Pathway (213818); Glutamatergic Synapse Pathway (213811); Hypothetical Network For Drug Addiction Pathway (198776); Long-term Depression Pathway (83086); Long-term Depression Pathway (497)

ncbi summary :

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG- Q- R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq]

uniprot summary :

GluR2: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) glutamate kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Protein type: Channel, ligand-gated; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 4q32.1. Cellular Component: postsynaptic membrane; synaptic vesicle; endoplasmic reticulum membrane; integral to plasma membrane; dendrite; plasma membrane; cell junction. Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity. Biological Process: synaptic transmission; synaptic transmission, glutamatergic; ionotropic glutamate receptor signaling pathway; signal transduction

size1 :

0.1 mg

price1 :

690 USD

more info or order :

MyBioSource product webpage