CD96 (CD96 Antigen, DKFZp667E2122, MGC22596, TACTILE, T cell-activated increased late expression protein, T-cell surface protein tactile precursor) | MyBioSource MBS605801 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CD96 (CD96 Antigen, DKFZp667E2122, MGC22596, TACTILE, T cell-activated increased late expression protein, T-cell surface protein tactile precursor)

catalog :

MBS605801

quantity :

0.1 mg

price :

885 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[9G159]

reactivity :

human

application :

flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS605801

products type :

Antibody

products full name :

CD96 (CD96 Antigen, DKFZp667E2122, MGC22596, TACTILE, T cell-activated increased late expression protein, T-cell surface protein tactile precursor)

products short name :

[CD96]

products name syn :

[Anti -CD96 (CD96 Antigen, DKFZp667E2122, MGC22596, TACTILE, T cell-activated increased late expression protein, T-cell surface protein tactile precursor)]

other names :

[CD96 antigen, isoform CRA_c; T-cell surface protein tactile; T-cell surface protein tactile; CD96 antigen; OTTHUMP00000214642; OTTHUMP00000214643; OTTHUMP00000214645; cell surface antigen CD96; T cell activation, increased late expression; t cell-activated increased late expression protein; CD96 molecule; Cell surface antigen CD96; T cell-activated increased late expression protein]

other gene names :

[CD96; CD96; TACTILE; MGC22596; DKFZp667E2122]

uniprot entry name :

TACT_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

[9G159]

host :

Mouse

reactivity :

Human

specificity :

Recognizes human CD96, also known as T cell-activated increased late expression (Tactile). Blocks binding of soluble poliovirus receptor (PVR) to NK92 cells.

purity :

Purified

form :

Supplied as a liquid in PBS, 0.1% BSA.

concentration :

0.1mg/ml

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeatedd freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

Flow Cytometry (FC/FACS)

app notes :

Suitable for use in Flow Cytometry and Funcional Studies. Blocks binding of soluble poliovirus receptor (PVR) to NK92 cells. Dilution: Flow Cytometry: 1:50. Functional Studies: Make according to the amounts of CD96 to be inactivated. Optimal dilutions to be determined by the researcher.

other info1 :

Immunogen: Human NK92 cells

other info2 :

Grade: Affinity Purified

products categories :

Antibodies; Abs to CD Markers

products description :

CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR or CD155). Furthermore CD96 stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. This means NK cells have due to the receptor CD96 a dual receptor system that recognizes nectins and nectin-like molecules on target cells and mediates NK cells adhesion and triggering of effector functions. As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors.

ncbi gi num :

119600104

uniprot acc num :

P40200

ncbi mol weight :

65,634 Da

ncbi pathways :

Adaptive Immunity Signaling Pathway (366160); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413)

ncbi summary :

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq]

uniprot summary :

CD96: May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation. Defects in CD96 are a cause of C syndrome (CSYN); also called Opitz trigonocephaly syndrome. This syndrome is characterized by trigonocephaly and associated anomalies, such as unusual facies, wide alveolar ridges, multiple buccal frenula, limb defects, visceral anomalies, redundant skin, psychomotor retardation and hypotonia. A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3q13.13-q13.2. Cellular Component: integral to plasma membrane; plasma membrane. Biological Process: regulation of immune response; immune response; cell adhesion. Disease: C Syndrome

size1 :

0.1 mg

price1 :

885 USD

more info or order :

MyBioSource product webpage