Macrophage inhibitory cytokine-1 (MIC-1) | MyBioSource MBS605694 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Macrophage inhibitory cytokine-1 (MIC-1)

catalog :

MBS605694

quantity :

0.05 mg

price :

460 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[9E99]

reactivity :

human

application :

ELISA, flow cytometry, FACS, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

FACS analysis of BOSC23 cells using MBS605694. BOSC23 cells were transiently transfected with an expression vector encoding either MIC-1 (red curve) or an irrelevant protein (control transfectant: black curve). Binding of MBS605694 was detected with a PE-conjugated secondary antibody. A positive signal was obtained only with MIC-1 transfected cells.

image 2 :

Capillary gel electrophoresis of MBS605694. Lane 1: molecular weight marker, Lane 2: MBS605694. Proteins were separated by CGE, Agilent 2100 Bioanalyzer. Internal control bands (240kD, 7kD, 4,5kD).

product information

catalog number :

MBS605694

products type :

Antibody

products full name :

Macrophage inhibitory cytokine-1 (MIC-1)

products short name :

[Macrophage inhibitory cytokine-1]

products name syn :

[Anti -Macrophage inhibitory cytokine-1 (MIC-1)]

other names :

[macrophage inhibitory cytokine-1; Growth/differentiation factor 15; growth/differentiation factor 15; NRG-1; PTGF-beta; placental TGF-beta; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; prostate differentiation factor; macrophage inhibitory cytokine 1; placental bone morphogenetic protein; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; growth differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor]

other gene names :

[GDF15; GDF15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; GDF15; MIC1; PDF; PLAB; PTGFB]

uniprot entry name :

GDF15_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

[9E99]

host :

Mouse

reactivity :

Human

specificity :

Recognizes native human Macrophage inhibitory cytokine-1.

purity :

Affinity Purified. Purified by Protein G affinity chromatography.

form :

Supplied as a liquid in PBS, pH 7.2.

concentration :

2mg/ml

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

ELISA (EL/EIA), Flow Cytometry (FC/FACS)

app notes :

Suitable for use in ELISA, Flow Cytometry and Immunoelectrophoresis. Dilution: ELISA: 1:200-1:400. Flow Cytometry: 1.2ug/10e6 cells

image1 heading :

Testing Data

image2 heading :

Testing Data

other info1 :

Immunogen: cDNA encoding aa30-194 from the N-terminal of human MIC-1 proprotein.

products categories :

Antibodies; Abs to Growth Factors, Cytokines

products description :

Macrophage inhibitory cytokine-1 (MIC-1) is a member of the transforming growth factor-beta superfamily that regulates a wide variety of physiological processes involved in tissue differentiation and maintenance (1). MIC-1 is synthesized as a 62kD intracellular protein, which, after cleavage by a furin like protease, is secreted as a 25kD disulphide-linked dimeric protein. Expression of MIC-1 results in inhibition of macrophage activation, regulated by the p53 pathway, in response to pro-inflammatory monokines (1,2). MIC-1 is involved in tumor pathogenesis and its measurement can be used as a clinical tool for the diagnosis of a wide range of cancers. It could be a useful marker for aggressive prostate cancer while MIC-1 is upregulated in advanced and more aggressive prostatic tumors (3).

ncbi gi num :

2674085

uniprot acc num :

Q99988

ncbi mol weight :

34,140 Da

ncbi pathways :

Direct P53 Effectors Pathway (137939)

ncbi summary :

Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM]

uniprot summary :

GDF15: disulfide-linked. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide; Cytokine. Chromosomal Location of Human Ortholog: 19p13.11. Cellular Component: extracellular space; extracellular region. Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: regulation of apoptosis; cell-cell signaling; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; signal transduction; cell development

size1 :

0.05 mg

price1 :

460 USD

size2 :

0.1 mg

price2 :

640

more info or order :

MyBioSource product webpage