antibody

B7H4 (B7-H4, B7S1, B7x, BC032925, Immune Costimulatory Protein B7H4, MGC41287, PRO1291, T Cell Costimulatory Molecule B7x, V Set Domain-containing T Cell Activation Inhibitor 1, VCTN1)

MBS604931

0.2 mg

640 USD

monoclonal

mouse

nonconjugated

[10B249]

Antibody

B7H4 (B7-H4, B7S1, B7x, BC032925, Immune Costimulatory Protein B7H4, MGC41287, PRO1291, T Cell Costimulatory Molecule B7x, V Set Domain-containing T Cell Activation Inhibitor 1, VCTN1)

[B7H4]

[Anti -B7H4 (B7-H4, B7S1, B7x, BC032925, Immune Costimulatory Protein B7H4, MGC41287, PRO1291, T Cell Costimulatory Molecule B7x, V Set Domain-containing T Cell Activation Inhibitor 1, VCTN1)]

[B7-H4 protein; Uncharacterized protein; V-set domain-containing T-cell activation inhibitor 1; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; immune costimulatory protein B7-H4; V-set domain containing T cell activation inhibitor 1]

[VTCN1; VTCN1; B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291; FLJ22418; RP11-229A19.4; VTCN1]

Q5T2L0_HUMAN

Monoclonal

IgG1

[10B249]

Mouse

Human

Recognizes human B7H4.

Affinity Purified. Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, 0.09% sodium azide.

1mg/ml

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). Other applications not tested.

Suitable for use in Flow Cytometry and Immunohistochemistry. Dilution: Flow Cytometry: 1:25-1:50; 10ul labels 10e6 cells in 100ul. Immunohistochemistry (Paraffin): 1:50. Does not require protein digestion pre-treatment of paraffin sections. Does not require antigen retrieval using heat treatment prior to staining paraffin sections. Immunohistochemistry: Frozen. Optimal dilutions to be determined by the researcher.

Immunogen: Human B7H4

Positive Control: Immunohistochemistry: Tonsil, breast carcinoma. Negative Control: I1904-78R: IgG1 Murine Negative Control

Antibodies; Abs to T Cells

B7H4, also known as B7x, is a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7H4 deficient mice are only minimally affected; suggesting B7H4 is important in the fine tuning of the T-cell mediated immune response. B7H4 is expressed on activate T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung. breast and ovary in humans. B7H4could be a useful prognostic marker in Renal Cell Carcinoma (RCC).

42357719

Q5T2L0

31,259 Da

B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM]

VTCN1: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p13.1. Cellular Component: integral to membrane; external side of plasma membrane. Molecular Function: receptor binding. Biological Process: response to protozoan; immune system process; positive regulation of T cell proliferation; negative regulation of T cell activation

0.2 mg

640 USD