Albumin, Human Serum, Glycated (HSA) | MyBioSource MBS604610 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Albumin, Human Serum, Glycated (HSA)

catalog :

MBS604610

quantity :

0.1 mg

price :

535 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8.F.7

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS604610

products type :

Antibody

products full name :

Albumin, Human Serum, Glycated (HSA)

products short name :

Albumin Serum, Glycated

products name syn :

Anti -Albumin, Human Serum, Glycated (HSA)

other names :

albumin; Serum albumin; serum albumin; OTTHUMP00000160370; OTTHUMP00000196832; OTTHUMP00000220435; OTTHUMP00000220436; OTTHUMP00000220438; OTTHUMP00000220439; growth-inhibiting protein 20; cell growth inhibiting protein 42; albumin

other gene names :

ALB; ALB; PRO0883; PRO0903; PRO1341; DKFZp779N1935

uniprot entry name :

ALBU_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

8.F.7

host :

Mouse

reactivity :

Human

specificity :

Recognizes glycated human albumin. Does not crossreact HbA1c, HbA1a, HbA1b, HbF and HbAo.

purity :

Affinity Purified. Purified by Protein G affinity chromatography.

form :

Supplied as a liquid in PBS, pH 7.4.

concentration :

1.77 mg/ml

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

ELISA (EL/EIA), Western Blot (WB)

app notes :

Suitable for use in ELISA and Western Blot. Recommended Dilutions: . Wester Blot: 1:1000. Optimal dilutions to be determined by the researcher.

other info1 :

Immunogen: Glycated human albumin

products categories :

Antibodies; Abs to Albumin

products description :

Human serum albumin is a single chain polypeptide which composes ~60% of the plasma proteins. In normal serum ~10% of the albumin is modified by non-enzymatic glycosylation which occurs primarily on lysine residue number 525. The amount of glycosylated albumin in serum is markedly elevated in diabetes and thus its determination may help in the monitoring of the disease. Studies also show that glycosylation of the protein alters its properties and this modification causes it to be ingested by endothelial cells in preference to unmodified albumin.

ncbi gi num :

178344

uniprot acc num :

P02768

ncbi mol weight :

69,367 Da

ncbi pathways :

Bile Acid And Bile Salt Metabolism Pathway (106144); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Formation Of Platelet Plug Pathway (106029); HDL-mediated Lipid Transport Pathway (106158); Hemostasis Pathway (106028); Lipid Digestion, Mobilization, And Transport Pathway (106111); Lipoprotein Metabolism Pathway (106156); Metabolism Of Lipids And Lipoproteins Pathway (160976); Platelet Activation Pathway (106034); Platelet Degranulation Pathway (106050)

ncbi summary :

Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq]

uniprot summary :

albumin: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Plasma. Belongs to the ALB/AFP/VDB family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Carrier; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 4q13.3. Cellular Component: extracellular space; protein complex; extracellular region; basement membrane; nucleus. Molecular Function: antioxidant activity; toxin binding; protein binding; enzyme binding; copper ion binding; DNA binding; zinc ion binding; chaperone binding; drug binding; oxygen binding; fatty acid binding; pyridoxal phosphate binding. Biological Process: platelet activation; receptor-mediated endocytosis; sodium-independent organic anion transport; bile acid metabolic process; maintenance of mitochondrion localization; hemolysis by symbiont of host red blood cells; lipoprotein metabolic process; cellular response to starvation; response to organic substance; bile acid and bile salt transport; response to mercury ion; retinal homeostasis; platelet degranulation; transport; negative regulation of programmed cell death; blood coagulation; positive regulation of circadian sleep/wake cycle, non-REM sleep; transmembrane transport; response to nutrient; negative regulation of apoptosis. Disease: Analbuminemia; Hyperthyroxinemia, Familial Dysalbuminemic

size1 :

0.1 mg

price1 :

535 USD

more info or order :

MyBioSource product webpage