antibody

Papilloma Virus, Human, Type 16/18, E7 (hPV)

MBS603982

1 mL

430 USD

monoclonal

mouse

nonconjugated

5E392

Antibody

Papilloma Virus, Human, Type 16/18, E7 (hPV)

Papilloma Virus, Type 16/18, E7

Anti -Papilloma Virus, Human, Type 16/18, E7 (hPV)

Monoclonal

IgG2a

5E392

Mouse

Recognizes the E7 protein of HPV types 16 & 18.

Affinity Purified. Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide. No stabilizing proteins have been added.

0.1mg/ml

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

ELISA (EL/EIA), Western Blot (WB). Other applications not tested.

Suitable for use in ELISA and Western Blot. Dilution: ELISA: 1:20-1:200. Western Blot: 1:10-1:50. Optimal dilutions to be determined by the researcher.

Immunogen: Papilloma Virus, Human, Type 16/18, E7.

Antibodies; Abs to Infectious Disease Papilloma

Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Some HPV types are the causative agents of cervical cancer, with types 16 and 18 being particularly high-risk. The viral proteins E6 and E7 disrupt normal cell cycle regulation by interacting with p53 (a tumor-suppressing transcription factor) and Rb (retinoblastoma protein, also a tumor-supressor). E7 particularly binds to Rb and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection.

1 mL

430 USD