Integrin beta6 | MyBioSource MBS603792 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Integrin beta6

catalog :

MBS603792

quantity :

0.1 mg

price :

680 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[2Q791]

reactivity :

human

application :

immunoprecipitation

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS603792

products type :

Antibody

products full name :

Integrin beta6

products short name :

[Integrin beta6]

products name syn :

[Anti -Integrin beta6]

other names :

[integrin beta-6; Integrin beta-6; integrin beta-6; OTTHUMP00000162896; OTTHUMP00000205127; OTTHUMP00000205128; OTTHUMP00000207333; integrin, beta 6]

other gene names :

[ITGB6; ITGB6; ITGB6]

uniprot entry name :

ITB6_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

[2Q791]

host :

Mouse

reactivity :

Human

specificity :

Recognizes human Integrin beta6.

purity :

Affinity Purified. Purified by affinity chromatography from ascites.

form :

Supplied as a liquid in PBS, pH 7.1. No preservatives added.

concentration :

1 mg/mL

storage stability :

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

Suitable for use in Flow Cytometry, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Not suitable for use in Function Blocking or Western Blot. Other applications have not been tested.

app notes :

Immunoprecipitation : Because MBS603792 is and IgG2a, protein Gor rabbit anti-mouse IgG is helpful for capture. Immunohistochemistry & Immunocytochemistry: Acetone fixed , Nuclear background staining limits usefulnesss in these techniques. Optimal dilution to be determined by researcher.

other info1 :

Immunogen: Murine NIH 3T3 cells stably transfected with the human b6 subunit.

products categories :

Antibodies; Abs to Integrin

products description :

Integrins are a large family of transmembrane proteins composed of an alpha and beta component. Integrins are involved in a diversity of biological functions such as cell adhesion, structure, differentiation, apoptosis and cell proliferation. They are the principal cell surface receptors that recognise cell to matrix interactions but little is known about the expression of beta 1 integrin family on airway smooth muscle (ASM) and their involvement in proliferation. This is a contributing factor in structural changes seen in asthma.

ncbi gi num :

9625002

ncbi acc num :

NP_000879.2

ncbi gb acc num :

NM_000888.3

uniprot acc num :

P18564

ncbi pathways :

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Hypertrophic Cardiomyopathy (HCM) Pathway (114229)

ncbi summary :

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

uniprot summary :

ITGB6: Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Belongs to the integrin beta chain family. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion. Chromosomal Location of Human Ortholog: 2q24.2. Cellular Component: plasma membrane; integrin complex; receptor complex; external side of plasma membrane. Molecular Function: integrin binding; viral receptor activity. Biological Process: integrin-mediated signaling pathway; entry of virus into host cell; extracellular matrix organization and biogenesis; multicellular organismal development; cell-matrix adhesion; cell adhesion; inflammatory response. Disease: Amelogenesis Imperfecta, Type Ih

size1 :

0.1 mg

price1 :

680 USD

more info or order :

MyBioSource product webpage