Neutrophil Defensin 5 (NP5) | MyBioSource MBS603525 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Neutrophil Defensin 5 (NP5)

catalog :

MBS603525

quantity :

0.1 mg

price :

835 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[6A609]

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry, FACS, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS603525

products type :

Antibody

products full name :

Neutrophil Defensin 5 (NP5)

products short name :

[Neutrophil Defensin 5]

products name syn :

[Anti -Neutrophil Defensin 5 (NP5)]

other names :

[neutrophil defensin 4 preproprotein; Neutrophil defensin 4; neutrophil defensin 4; corticostatin; defensin, alpha 4, preproprotein; defensin, alpha 4, corticostatin; Defensin, alpha 4; HNP-4]

other gene names :

[DEFA4; DEFA4; HP4; DEF4; HP-4; HNP-4; DEF4; HP-4]

uniprot entry name :

DEF4_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

[6A609]

host :

Mouse

reactivity :

Rabbit

specificity :

Recognizes natural, synthetic and recombinant rabbit Neutrophil Defensin 5. Reacts with natural NP-5 in biological solutions, in tissue sections and leukocyte smears fixed with ethanol, methanol/acetone or paraformaldehyde and in Flow Cytometry analysis of rabbit neutrophils stained by cell permeabilization method.

purity :

Affinity Purified. Purified by Protein G affinity chromatography.

form :

Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.

concentration :

0.1mg/ml

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

app notes :

Suitable for use in ELISA, Western Blot, Flow Cytometry and Immunohistochemistry. Dilution: Western Blot: 1:10. Flow Cytometry: 1:10. Immunohistochemistry (Paraffin, frozen): 1:10

other info1 :

Immunogen: Rabbit Neutrophil Defensin 5 (NP5).

products categories :

Antibodies; Abs to Defensin

products description :

Alpha defensins belong together with the beta-defensins to the family of cationic trisulfide-containing microbicidal peptides. They exert their microbicidal activity by permeating the membrane involving the formation of voltage regulated ion channels. Rabbit neutrophils contain large amount of alpha defensins (Neutrophil Defensin) NP 1-6. Defensins constitute more than 15% of total protein in rabbit neutrophils and are accumulated in dense cytoplasmic granules. Rabbit neutrophils express all six rabbit alpha-defensins, NP 1-6. Among myeloid rabbit alpha-defensins NP 1-6, NP 3-6 are neutrophil specific, while NP 1-2 are expressed in rabbit alveolar macrophages. Defensins are relatively resistant to proteolysis, low pH and boiling. Rabbit neutrophil defensins, whose three-dimensional structures are very similar to those of human alpha defensins may be helpful in understanding the role of antimicrobial peptides in innate and acquired immunity and in the studies on the role of neutrophils in pathological situations and in various rabbit models of human diseases.

ncbi gi num :

4503303

ncbi acc num :

NP_001916.1

ncbi gb acc num :

NM_001925.1

uniprot acc num :

P12838

ncbi mol weight :

10,504 Da

ncbi pathways :

Alpha-defensins Pathway (530758); Defensins Pathway (530757); Immune System Pathway (106386); Innate Immune System Pathway (106387)

ncbi summary :

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Jul 2008]

uniprot summary :

DEFA4: Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production. Belongs to the alpha-defensin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 8p23. Cellular Component: extracellular space; Golgi lumen; extracellular region. Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus

size1 :

0.1 mg

price1 :

835 USD

more info or order :

MyBioSource product webpage