catalog number :
MBS602760
products full name :
Oligodendrocytes
products short name :
Oligodendrocytes
products name syn :
Anti -Oligodendrocytes
other names :
oligodendrocyte transcription factor 1; Oligodendrocyte transcription factor 1; oligodendrocyte transcription factor 1; oligo1; class B basic helix-loop-helix protein 6; class E basic helix-loop-helix protein 21; oligodendrocyte lineage transcription factor 1; basic domain, helix-loop-helix protein, class B, 6; oligodendrocyte-specific bHLH transcription factor 1; oligodendrocyte transcription factor 1; Class B basic helix-loop-helix protein 6; bHLHb6; Class E basic helix-loop-helix protein 21
other gene names :
OLIG1; OLIG1; BHLHB6; BHLHE21; BHLHB6; BHLHE21; Oligo1; bHLHb6; bHLHe21
uniprot entry name :
OLIG1_HUMAN
reactivity :
Hamster, Human, Mouse, Rat
specificity :
Recognizes rat Oligodendrocytes. Reacts with oligodendrocytes and their myelin sheaths. Stains both early and mature oligodendrocytes. Species crossreactivity: mouse, human and hamster.
purity :
Ascites. Ascites
form :
Supplied as a liquid, 0.1% sodium azide.
storage stability :
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
tested application :
Immunohistochemistry (IHC), Immunocytochemistry (ICC)
app notes :
Suitable for use in Immunohistochemistry and Immunocytochemistry. Dilution: Immunohistochemistry: 1:200,000 on 4% paraformaldehyde fixed tissue.
other info1 :
Immunogen: Rat olfactory bulb extract
products categories :
Antibodies; Abs to Proteins
products description :
This protein is found exclusively on oligodendrocytes and myelin in the central nervous system (CNS). Myelin is produced by oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system (PNS). Defining the differences between CNS and PNS myelin may provide insights into the process of myelination and the pathogenesis of certain idiopathic diseases involving myelin such as multiple sclerosis, certain leukodystrophies, and other myelinopathies. On de-myelination, immunoreactivity for MOSP, like MBP, is lost.
ncbi acc num :
NP_620450.2
ncbi gb acc num :
NM_138983.2
ncbi mol weight :
27,905 Da
ncbi pathways :
Neural Crest Differentiation Pathway (672460)
uniprot summary :
OLIG1: Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube. Protein type: Cell development/differentiation; Transcription factor. Chromosomal Location of Human Ortholog: 21q22.11. Cellular Component: nucleus. Molecular Function: protein dimerization activity; protein binding; DNA binding. Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; neuron fate commitment