MyBioSource

antibody

c-Abl (ABL1, v-abl, Abelson Murine Leukemia Viral Oncogene Homolog 1, ABL, c-ABL, JTK7, p150, Proto-Oncogene Tyrosine-Protein Kanase ABL1, v-abl)

MBS602512

0.5 ml

705 USD

monoclonal

mouse

human, mouse

immunoprecipitation, western blot, immunohistochemistry, immunocytochemistry

MBS602512

Antibody

c-Abl (ABL1, v-abl, Abelson Murine Leukemia Viral Oncogene Homolog 1, ABL, c-ABL, JTK7, p150, Proto-Oncogene Tyrosine-Protein Kanase ABL1, v-abl)

c-Abl

Anti -c-Abl (ABL1, v-abl, Abelson Murine Leukemia Viral Oncogene Homolog 1, ABL, c-ABL, JTK7, p150, Proto-Oncogene Tyrosine-Protein Kanase ABL1, v-abl)

c-abl; C-abl; tyrosine-protein kinase ABL1; proto-oncogene c-Abl; bcr/c-abl oncogene protein; c-abl oncogene 1, receptor tyrosine kinase; proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, non-receptor tyrosine kinase; N/A

ABL1; ABL1; ABL; JTK7; p150; c-ABL; v-abl; bcr/abl; ABL1; N/A

Q13915_HUMAN

Monoclonal

IgG1 lambda

8J414

Mouse

Human, Mouse

Reacts with c-Abl p120 and chimeric Bcr / Abl proteins. Species Crossreactivity: Crossreacts with Human and Mouse. Not yet tested in other species.

Affinity Purified. Purified by Protein G affinity chromatography.

10mM PBS, pH7.4, 0.2%BSA,

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)

Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation and Immunohistochemistry (paraffin-embedded sections).

Immunogen: Recombinant full length protein. Epitope: SH2 domain. Cellular Localization: Cytoplasmic and Nuclear

Positive Control: HeLa cells or placenta.

Antibodies; Abs to Oncoproteins

The c-Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) as the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr / Abl mRNA encoding activated Abl protein tyrosine kinase.

179750

Q13915

13,150 Da

Alpha6-Beta4 Integrin Signaling Pathway 198807!!Axon Guidance Pathway 83065!!Axon Guidance Pathway 476!!Axon Guidance Pathway 105688!!CDO In Myogenesis Pathway 160998!!Cell Cycle Pathway 198811!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!Chronic Myeloid Leukemia Pathway 83116!!Chronic Myeloid Leukemia Pathway 528

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq]

Sequence similarities: Contains 1 SH3 domain. RuleBase RU003338

0.5 ml

705 USD