antibody

a-Fetoprotein Receptor (AFPr)

MBS602268

1 mg

580 USD

monoclonal

mouse

nonconjugated

1.B.816

western blot, immunocytochemistry

Antibody

a-Fetoprotein Receptor (AFPr)

a-Fetoprotein Receptor

Anti -a-Fetoprotein Receptor (AFPr)

alpha1-fetoprotein transcription factor; Nuclear receptor subfamily 5 group A member 2; nuclear receptor subfamily 5 group A member 2; nuclear receptor NR5A2; liver receptor homolog 1; liver receptor homolog-1; CYP7A promoter-binding factor; hepatocytic transcription factor; alpha-1-fetoprotein transcription factor; liver nuclear receptor homolog-1 variant 2; fetoprotein-alpha 1 (AFP) transcription factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; nuclear receptor subfamily 5, group A, member 2; Alpha-1-fetoprotein transcription factor; B1-binding factor; hB1F; CYP7A promoter-binding factor; Hepatocytic transcription factor; Liver receptor homolog 1

NR5A2; NR5A2; B1F; CPF; FTF; B1F2; LRH1; LRH-1; FTZ-F1; hB1F-2; FTZ-F1beta; B1F; CPF; FTF; hB1F; LRH-1

NR5A2_HUMAN

Monoclonal

IgG2a

1.B.816

Host: Mouse; Source: Human

Human

Recognizes the determinant of human alpha-fetoprotein receptor. Does not react with human IgG.

Affinity Purified. Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB), Immunocytochemistry (ICC)

Suitable for use in Immunocytochemistry, Western Blot and as an AFP/AFP-R blocker.

Immunogen: Purified human alpha-fetoprotein receptor.

Hybridoma: Sp2/0 myeloma cells with spleen cells from Balb/c mice.

Antibodies; Abs to Receptors

1947098

AAD03155.1

O00482

61,331 Da

Developmental Biology Pathway 477129!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!Maturity Onset Diabetes Of The Young Pathway 83096!!Maturity Onset Diabetes Of The Young Pathway 508!!Nuclear Receptor Transcription Pathway 105979!!Nuclear Receptors Pathway 198848!!Regulation Of Beta-cell Development Pathway 106328!!Regulation Of Gene Expression In Early Pancreatic Precursor Cells Pathway 106329

Function: Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Subunit structure: Binds DNA as a monomer . By similarity. Interacts with GRIP1, NCOA2 and NR0B2. Subcellular location: Nucleus . Probable. Tissue specificity: Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells. Sequence similarities: Belongs to the nuclear hormone receptor family. NR5 subfamily.Contains 1 nuclear receptor DNA-binding domain.

1 mg

580 USD