catalog number :
MBS601976
products full name :
Cholera Toxin, beta, Vibrio cholerae
products short name :
Cholera Toxin, beta, Vibrio cholerae
products name syn :
Anti -Cholera Toxin, beta, Vibrio cholerae
other names :
cholera toxin
specificity :
Recognizes the labile entertoxin normally associated with Vibrio cholerae and reacts with an epitope on the beta chain. No crossreactivity with various E. coli serotypes.
purity :
Affinity Purified. Purified by Protein G affinity chromatography
form :
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
storage stability :
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
tested application :
ELISA (EL/EIA), Immunohistochemistry (IHC)
app notes :
Suitable for use in ELISA and Immunohistochemistry. Dilution: Immunohistochemistry: Frozen sections
other info1 :
Immunogen: Vibrio cholera
products categories :
Antibodies; Abs to Infectious Disease Cholera
products description :
Cholera toxin is an oligomeric protein of MW 84kD and consists of a single A subunit surrounded by five B subunits. It is a potent activator of adenylate cyclase and is the pathogenic agent responsible for the symptoms of cholera. The B subunit (choleragenoid) is responsible for the binding of the holotoxin to G M1 ganglioside receptors on mammalian cell surfaces and facilitates entrance of the A subunit into the cell. The A subunit bears the ADP-ribosyl-transferase activity, which deregulates the G sprotein causing activation of adenylate cyclase. Due to the ubiquitous occurrence of the GM1 ganglioside receptor on eukaryotic cell membranes, cholera toxin activates adenylate cyclase in a wide variety of systems.
ncbi acc num :
ACF35010.1