antibody

DLL3 (Delta-like Protein 3, Drosophila Delta Homolog 3, Delta3)

MBS601745

0.1 mg

695 USD

monoclonal

mouse

nonconjugated

[7H171]

western blot, ELISA, enzyme immunoassay

Antibody

DLL3 (Delta-like Protein 3, Drosophila Delta Homolog 3, Delta3)

[DLL3]

[Anti -DLL3 (Delta-like Protein 3, Drosophila Delta Homolog 3, Delta3)]

[delta-like protein 3 isoform 2; Delta-like protein 3; delta-like protein 3; delta3; drosophila Delta homolog 3; delta-like 3 (Drosophila); Drosophila Delta homolog 3]

[DLL3; DLL3; SCDO1; Delta3]

DLL3_HUMAN

Monoclonal

IgG2b

[7H171]

Mouse

Human

Recognizes human DLL3. Does not crossreact with recombinant human DLL1 or recombinant human DLL4.

Purified by Protein A affinity chromatography.

Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.

~0.5mg/ml(after reconstitution)

Lyophilized powder may be stored at -20 degree C. Stable for 12 months after receipt at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

ELISA (EL/EIA), Western Blot (WB)

Western Blot: 1ug/ml using recombinant human DLL3. Optimal dilutions to be determined by the researcher.

Immunogen: Recombinant protein corresponding to Ala27-Pro488 from human DLL3 expressed in CHO cells. UniProt Accession #Q9NYJ7. Grade: Affinity Purified

Antibodies; Abs to Notch Proteins

Delta-like 3 (DLL3) is a transmembrane Delta-like protein that contains one DSL domain and six EGF-like repeats. DLL3 is critical for somite segmentation and neurogenesis during early embryonic development. It does not bind Notch receptors but functions as an antagonist of Notch signaling. Defects in DLL3 cause axial skeletal abnormalities in spondylocostal dysostosis. Within the extracellular domain, human DLL3 shares 84% amino acid sequence identity with mouse and rat DLL3.

45243561

NP_982353.1

NM_203486.2

Q9NYJ7

Neural Crest Differentiation Pathway (672460); Notch Signaling Pathway (198891); Notch Signaling Pathway (83062); Notch Signaling Pathway (169345); Notch Signaling Pathway (473)

This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

DLL3: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Can bind and activate Notch-1 or another Notch receptor. Protein type: Cell development/differentiation; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13. Cellular Component: integral to membrane. Molecular Function: Notch binding. Biological Process: compartment specification; paraxial mesoderm development; Notch signaling pathway; somitogenesis; skeletal development; negative regulation of neurogenesis. Disease: Spondylocostal Dysostosis 1, Autosomal Recessive

0.1 mg

695 USD