NPFFR2 (Neuropeptide FF Receptor 2, G-protein Coupled Receptor 74, G-protein Coupled Receptor HLWAR77, Neuropeptide G-protein Coupled Receptor, GPR74, NPFF2, NPGPR) | MyBioSource MBS6012479 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

NPFFR2 (Neuropeptide FF Receptor 2, G-protein Coupled Receptor 74, G-protein Coupled Receptor HLWAR77, Neuropeptide G-protein Coupled Receptor, GPR74, NPFF2, NPGPR)

catalog :

MBS6012479

quantity :

0.1 mg

price :

500 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of human brain lysate 20ug per wel using MBS6012479 at 1:500 dilution. Lane 1: MBS6012479 detects a 60kD and a 49kD doublet. Lane 2: Negative control (antibody preincubated with peptide).

product information

catalog number :

MBS6012479

products type :

Antibody

products full name :

NPFFR2 (Neuropeptide FF Receptor 2, G-protein Coupled Receptor 74, G-protein Coupled Receptor HLWAR77, Neuropeptide G-protein Coupled Receptor, GPR74, NPFF2, NPGPR)

products short name :

[NPFFR2]

products name syn :

[Anti -NPFFR2 (Neuropeptide FF Receptor 2, G-protein Coupled Receptor 74, G-protein Coupled Receptor HLWAR77, Neuropeptide G-protein Coupled Receptor, GPR74, NPFF2, NPGPR)]

other names :

[neuropeptide FF receptor 2 isoform 1; Neuropeptide FF receptor 2; neuropeptide FF receptor 2; neuropeptide FF 2; G protein-coupled receptor 74; G-protein coupled receptor 74; G-protein coupled receptor HLWAR77; neuropeptide G-protein coupled receptor; neuropeptide FF receptor 2; G-protein coupled receptor 74; G-protein coupled receptor HLWAR77; Neuropeptide G-protein coupled receptor]

other gene names :

[NPFFR2; NPFFR2; GPR74; NPFF2; NPGPR; HLWAR77; GPR74; NPFF2; NPGPR]

uniprot entry name :

NPFF2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

specificity :

Recognizes human NPFF2. Species Crossreactivity: mouse.

purity :

Affinity Purified. Purified by Protein G affinity chromatography.

form :

Supplied as a liquid in PBS, 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

Western Blot (WB)

app notes :

Suitable for use in Western Blot. Dilution: Western Blot: 1:500-1:1000

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: Synthetic peptide corresponding to human NPFF2.

products categories :

Antibodies; Abs to G Protein Receptors

products description :

NPFF2, a 60kD transmembrane protein, is a G-protein coupled NPFF receptor & shares homology with the seven trans-membrane domain receptor super family. It has a tissue-restricted distribution and consists of a 147-residue-N-terminal domain, 7 transmembrane domains and a C-terminal domain. It binds NPFF and might play a role in pain modulation and opiate tolerance. Reports suggest NPFF2 binds Prolactin releasing peptide and mediates its signaling. Northern Blot analysis detected a high expression of NPFF2 transcript in placenta, testis, thymus and small intestine with a moderate expression in other tissues.

ncbi gi num :

221316654

ncbi acc num :

NP_004876

ncbi gb acc num :

NM_004885.2

uniprot acc num :

Q9Y5X5

ncbi mol weight :

60,270 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Orexin And Neuropeptides FF And QRFP Bind To Their Respective Receptors Pathway (106362); Peptide Ligand-binding Receptors Pathway (106358)

ncbi summary :

This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

uniprot summary :

NPFFR2: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 4q21. Cellular Component: integral to plasma membrane; plasma membrane; actin cytoskeleton. Molecular Function: G-protein coupled receptor activity; opioid receptor binding; neuropeptide receptor activity; peptide binding. Biological Process: regulation of adenylate cyclase activity; G-protein coupled receptor protein signaling pathway; synaptic transmission; neuropeptide signaling pathway; regulation of MAPKKK cascade; detection of abiotic stimulus; cellular response to hormone stimulus

size1 :

0.1 mg

price1 :

500 USD

more info or order :

MyBioSource product webpage