CYP19A1, ID (Cytochrome P450 19A1, CYPXIX, Estrogen Synthetase, P-450AROM, Aromatase, Cytochrome P-450AROM, ARO1, CYAR, CYP19) | MyBioSource MBS6011765 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CYP19A1, ID (Cytochrome P450 19A1, CYPXIX, Estrogen Synthetase, P-450AROM, Aromatase, Cytochrome P-450AROM, ARO1, CYAR, CYP19)

catalog :

MBS6011765

quantity :

0.05 mg

price :

695 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of human Placenta lysate (35ug protein in RIPA buffer) using MBS6011765 (0.1ug/ml). Primary incubation was 1 hour. Detected by chemiluminescence.

image 2 :

Immunohistochemistry analysis of formalin-fixed, paraffin-embedded human Placenta using MBS6011765 (4ug/ml) followed by biotinylated goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.

product information

catalog number :

MBS6011765

products type :

Antibody

products full name :

CYP19A1, ID (Cytochrome P450 19A1, CYPXIX, Estrogen Synthetase, P-450AROM, Aromatase, Cytochrome P-450AROM, ARO1, CYAR, CYP19)

products short name :

[CYP19A1]

products name syn :

[Anti -CYP19A1, ID (Cytochrome P450 19A1, CYPXIX, Estrogen Synthetase, P-450AROM, Aromatase, Cytochrome P-450AROM, ARO1, CYAR, CYP19)]

other names :

[cytochrome P450 19A1; Cytochrome P450 19A1; cytochrome P450 19A1; aromatase; estrogen synthase; estrogen synthetase; cytochrome P-450AROM; microsomal monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily XIX (aromatization of androgens); cytochrome P450, family 19, subfamily A, polypeptide 1; Aromatase; CYPXIX; Cytochrome P-450AROM; Estrogen synthase]

other gene names :

[CYP19A1; CYP19A1; ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM; ARO1; CYAR; CYP19]

uniprot entry name :

CP19A_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Goat

reactivity :

Human

specificity :

Recognizes human CYP19A1.

purity :

Purified by immunoaffinity chromatography

form :

Supplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide.

concentration :

0.5mg/ml

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Suitable for use in Western Blot, ELISA and Immunohistochemistry. Dilution: ELISA: 1:128,000. Western Blot: 0.1-0.3ug/ml. Immunohistochemistry (Formalin fixed paraffin embedded): 4ug/ml - Requires HIER citrate buffer, pH 6.0. Optimal dilutions to be determined by the researcher.

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Synthetic peptide corresponding to C-HDLSLHPDETKN of human CYP19A1. Grade: Affinity Purified

products categories :

Antibodies; Abs to Enzymes, Cytochrome

products description :

CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.

ncbi gi num :

13904860

ncbi acc num :

NP_112503.1

ncbi gb acc num :

NM_031226.2

uniprot acc num :

P11511

ncbi pathways :

Biological Oxidations Pathway (105698); C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway (413383); C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway (468268); Cytochrome P450 - Arranged By Substrate Type Pathway (105700); Endogenous Sterols Pathway (105701); Estrogen Biosynthesis Pathway (106155); FSH Signaling Pathway (672455); Integrated Breast Cancer Pathway (219801); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976)

ncbi summary :

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq, Jul 2008]

uniprot summary :

CYP19A1: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family. Protein type: Oxidoreductase; EC 1.14.14.14; Lipid Metabolism - androgen and estrogen. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum. Molecular Function: electron carrier activity; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; oxygen binding. Biological Process: steroid metabolic process; xenobiotic metabolic process; androgen metabolic process; steroid biosynthetic process; estrogen biosynthetic process; sterol metabolic process. Disease: Aromatase Deficiency; Aromatase Excess Syndrome

size1 :

0.05 mg

price1 :

695 USD

more info or order :

MyBioSource product webpage