ITGA5, ID (ITGA5, FNRA, Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain) | MyBioSource MBS6011589 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ITGA5, ID (ITGA5, FNRA, Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain)

catalog :

MBS6011589

quantity :

0.2 mL

price :

610 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of ITGA5 in 293 cell lysates (2 ug/lane) either non-transfected (Lane ) or transiently transfected (Lane 2) with the ITGA5 gene.

image 2 :

Immunohistochemistry analysi of formalin fixed and paraffin embedded human placenta tissue/. Peroxidase-conjugated secondary antibody and DAB staining were used for visualization.

image 3 :

Western blot analysis of human uterine tumor and mouse bladder tissue lysates (35ug/lane).

product information

catalog number :

MBS6011589

products type :

Antibody

products full name :

products short name :

[ITGA5]

products name syn :

[Anti -ITGA5, ID (ITGA5, FNRA, Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain)]

other names :

[integrin alpha-5; Integrin alpha-5; integrin alpha-5; VLA-5; integrin alpha-F; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronectin receptor, alpha subunit; very late activation protein 5, alpha subunit; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5]

other gene names :

[ITGA5; ITGA5; FNRA; CD49e; VLA5A; FNRA]

uniprot entry name :

ITA5_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

specificity :

Recognizes Human ITGA5

purity :

Affinity Purified. Purified by Protein A affinity chromatography.

form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

concentration :

0.72 mg/ml

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Suitable for use in Western Blot, Immunohistochemistry, . Dilution: Western Blot: 1:100-1:500. Immunohistochemistry: 1:10-1:50. Optimal dilutions to be determined by the researcher.

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Western Blot (WB)

other info1 :

Immunogen: Sythetic peptide corresponding to aa575-602 from the internal reigon of human ITGA5 conjugated with KLH (P08648). Species sequence homology: mouse

products categories :

Antibodies; Abs to Fibronectin

products description :

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].

ncbi gi num :

56237029

ncbi acc num :

NP_002196.2

ncbi gb acc num :

NM_002205.2

uniprot acc num :

P08648

ncbi pathways :

Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (105688); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); Cell Surface Interactions At The Vascular Wall Pathway (106062); Developmental Biology Pathway (477129); Dilated Cardiomyopathy Pathway (121494)

ncbi summary :

uniprot summary :

ITGA5: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi s sarcoma lesions. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV- 1 Tat. Belongs to the integrin alpha chain family. Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 12q11-q13. Cellular Component: ruffle; focal adhesion; cell surface; cytoplasm; plasma membrane; synapse; intercellular junction; integrin complex; external side of plasma membrane. Molecular Function: integrin binding; protein binding; vascular endothelial growth factor receptor 2 binding; metal ion binding; platelet-derived growth factor receptor binding; epidermal growth factor receptor binding. Biological Process: integrin-mediated signaling pathway; axon guidance; extracellular matrix organization and biogenesis; viral reproduction; cell-substrate adhesion; memory; positive regulation of vascular endothelial growth factor receptor signaling pathway; heterophilic cell adhesion; heterotypic cell-cell adhesion; leukocyte adhesion; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell adhesion mediated by integrin; cell-substrate junction assembly; angiogenesis; blood coagulation; cell adhesion; leukocyte migration; wound healing, spreading of epidermal cells; positive regulation of cell migration

size1 :

0.2 mL

price1 :

610 USD

more info or order :

MyBioSource product webpage