antibody

MCP-8 (Mast Cell Protease 8, Mcpt8)

MBS6010758

0.025 mg

370 USD

monoclonal

rat

nonconjugated

mouse, rat

Antibody

MCP-8 (Mast Cell Protease 8, Mcpt8)

[MCP-8]

[Anti -MCP-8 (Mast Cell Protease 8, Mcpt8)]

[membrane cofactor protein; Membrane cofactor protein; membrane cofactor protein; CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein]

[Cd46; Cd46; Mcp; Mcp]

MCP_RAT

Monoclonal

IgG2a

Rat

Mouse

Recognizes mouse Mast Cell Protease 8.

Purified by affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

0.5mg/ml

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

Suitable for use in Western Blot. Dilution: Western Blot: 1-2ug/ml

Western Blot (WB)

Immunogen: Recombinant GST-mouse mMCP-8 fusion protein expressed in E.coli.

Antibodies; Abs to Enzymes

mMCP-8 and its rat homologues, rMCP-8, -9, and -10, form a new group of mast cell/basophil proteases, which are more closely related to the T-cell granzymes and neutrophil cathepsin G than to the mast cell tryptases and chymases. mMCP-8 showed a high degree of homology with mouse granzyme B in the critical regions for determining substrate cleavage specificity. It preferentially cleaves after Asp residues. mMCP-8 mRNA is highly expressed in a mouse connective tissue MC-like tumor line. However, it could not be detected in mouse liver, intestine, lung or ears, indicating very low expression in normal tissues. A strong increase in mMCP-8 levels in the lungs can be detected in infected animals.

9506883

NP_062063.1

NM_019190.1

Q9Z0M4

Complement And Coagulation Cascades Pathway (198461); Complement And Coagulation Cascades Pathway (83465); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (829106); Immune System Pathway (829042); Innate Immune System Pathway (829071); Measles Pathway (213300); Measles Pathway (213277); Regulation Of Complement Cascade Pathway (829114)

may be involved in fertilization or reproduction; human homolog acts as an inhibitor of plasma membrane complement [RGD, Feb 2006]

Function: May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Ref.2 Ref.3. Subcellular location: Cytoplasmic vesicle secretory vesicle acrosome inner membrane; Single-pass membrane protein. Note: Inner acrosomal membrane of spermatozoa. Ref.3. Tissue specificity: Specifically expressed in testis. Within testis, present only in elongated spermatids and spermatozoa (at protein level). Ref.1 Ref.2 Ref.3. Developmental stage: Not expressed in embryonic and immature rats. Expressed in parallel with synthesis of spermatids. Ref.3. Post-translational modification: O-glycosylated. Ref.3N-glycosylated. Ref.3. Sequence similarities: Contains 4 Sushi (CCP/SCR) domains.

0.025 mg

370 USD

0.1 mg

520