antibody

MRGPRX2 (MRGX2, Mas-related G-protein Coupled Receptor Member X2)

MBS6010259

0.05 mg

580 USD

polyclonal

mouse

nonconjugated

western blot, flow cytometry

Antibody

MRGPRX2 (MRGX2, Mas-related G-protein Coupled Receptor Member X2)

[MRGPRX2]

[Anti -MRGPRX2 (MRGX2, Mas-related G-protein Coupled Receptor Member X2)]

[mas-related G-protein coupled receptor member X2; Mas-related G-protein coupled receptor member X2; mas-related G-protein coupled receptor member X2; G protein-coupled receptor MRGX2; MAS-related GPR, member X2]

[MRGPRX2; MRGPRX2; MRGX2; MRGX2]

MRGX2_HUMAN

Polyclonal

IgG

Mouse

Human

MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILF
IALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLF
LCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGL
SMLSTVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWAL
SLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLIFLF
MVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLL
CGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSS
ANPIIYFFVGSFRKQWRLQQPILKLALQRALQDIAEVDH
SEGCFRQGTPEMSRSSLV

Recognizes human MRGPRX2.

Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.4.

0.36mg/ml

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB), Flow Cytometry (FC)

Suitable for use in Western Blot and Flow Cytometry. Other applications not tested. Optimal dilutions to be determined by the researcher.

Western Blot (WB)

Flow Cytometry (FC/FACS)

Immunogen: Full length human MRGPRX2, aa1-330 (NP_473371.1).

Antibodies; Abs to G Protein Receptors

MRGPRX2 is the orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.

16876451

NP_473371.1

NM_054030.2

Q96LB1

MRGPRX2: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin- stimulated cAMP levels, suggesting that this receptor is G(q)- coupled. Belongs to the G-protein coupled receptor 1 family. Mas subfamily. Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11p15.1. Cellular Component: integral to membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; neuropeptide binding. Biological Process: positive regulation of cytokinesis; G-protein coupled receptor protein signaling pathway; sensory perception of pain; sleep

0.05 mg

580 USD