This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
Naked2 (Nkd2)
catalog :
MBS600773
quantity :
0.1 ml
price :
455 USD
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
8A19
reactivity :
mouse, zebrafish
application :
western blot, immunoprecipitation
product information
catalog number :
MBS600773
products type :
Antibody
products full name :
Naked2 (Nkd2)
products short name :
Naked2
products name syn :
Anti -Naked2 (Nkd2)
other names :
naked 2b; Protein naked cuticle homolog 2-like; protein naked cuticle homolog 2-like; naked cuticle homolog 2b; Protein naked cuticle homolog 2-B
other gene names :
nkd2b; nkd2l; nkd2; nkd2l; nkd2b; Naked-2-like; Naked-2B
uniprot entry name :
NKD2L_DANRE
clonality :
Monoclonal
isotype :
IgG
clone :
8A19
host :
Host: Rabbit; Source: Mouse
reactivity :
Mouse
specificity :
Detects transfected levels of mouse Naked2.
purity :
As reported
form :
Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/mlBSA, 50% glycerol, 0.02% sodium azide.
storage stability :
For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
tested application :
Western Blot (WB), Immunoprecipitation (IP)
app notes :
Suitable for use in Western Blot and Immunoprecipitation. Dilution: Western Blot: 1:1000. IImmunoprecipitation: 1:50
other info1 :
Immunogen: Synthetic peptide (KLH-coupled) corresponding to residues surrounding Gly47 of mouse Naked2.
products categories :
Antibodies; Abs to Wnt Proteins
products description :
Naked1 (Nkd1) and Naked2 (Nkd2) are homologs of Drosophila Naked cuticle, a negative regulator of Wnt/Wingless signaling pathway which functions through a feedback mechanism (1,2). Both Drosophila and vertebrate Naked proteins contain a putative calcium-binding EF-hand motif; however, Drosophila Naked binds to zinc instead of calcium (3). Naked inhibits the canonical Wnt/ -catenin pathway by binding to Dishevelled proteins and directs Dishevelled activity towards the planar cell polarity pathway (2,4). Naked1 is a direct target of Wnt signaling and is overexpressed in some colon tumors due to constitutive activation of Wnt/ -catenin pathway (5). Naked2 is myristoylated and is required for sorting of TGF- to the basolateral plasma membrane of polarized epithelial cells (6).
ncbi gi num :
145076869
ncbi acc num :
ABP35565.1
uniprot acc num :
A4ZNR5
ncbi mol weight :
47,136 Da
ncbi pathways :
Wnt Signaling Pathway 83638!!Wnt Signaling Pathway 471
uniprot summary :
Function: Cell autonomous antagonist of both the canonical and non-canonical Wnt signaling pathways . By similarity. Subcellular location: Cell membrane . By similarity. Cytoplasm . By similarity. Sequence similarities: Belongs to the NKD family.Contains 1 EF-hand domain.
size :
0.1 ml
price :
455 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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