product summary
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company name :
MyBioSource
product type :
antibody
product name :
DAG1, CT (DAG1, Dystroglycan, Dystrophin-associated glycoprotein 1, Alpha-dystroglycan, Beta-dystroglycan)
catalog :
MBS6007719
quantity :
0.2 mL
price :
610 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
Xenopus laevis
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
image
image 1 :
Western Blot analysis of mouse NIH-3T3 cell line lysates (35ug/lane) using MBS6007719. This demonstrates that MBS6007719 detected the DAG1 protein (arrow).
image 2 :
Immunohistochemistry analysis of formalin fixed and paraffin embedded human skeletal muscle using MBS6007719 followed by peroxidase conjugation of the secondary antibody and DAB staining
product information
catalog number :
MBS6007719
products type :
Antibody
products full name :
DAG1, CT (DAG1, Dystroglycan, Dystrophin-associated glycoprotein 1, Alpha-dystroglycan, Beta-dystroglycan)
products short name :
[DAG1]
products name syn :
[Anti -DAG1, CT (DAG1, Dystroglycan, Dystrophin-associated glycoprotein 1, Alpha-dystroglycan, Beta-dystroglycan)]
other names :
[dystroglycan 1; dystroglycan 1]
other gene names :
[dag1]
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
specificity :
Recognizes Human DAG1
purity :
Purified by Protein A affinity chromatography.
form :
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
concentration :
0.61 mg/ml
storage stability :
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
tested application :
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Dilution:. Western Blot: 1:1000. Immunohistochemistry (FFPE): 1:10-50
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 718-747 in the C-terminal region of human DAG1. Grade: Affinity Purified. Species Sequence Homology: Porcine and Rabbit.
products categories :
Antibodies; Abs to Carbohydrates, Glycoproteins
products description :
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
ncbi gi num :
148232988
ncbi acc num :
NP_001171107.1
ncbi gb acc num :
NM_001087286.1
uniprot acc num :
Q14118
ncbi pathways :
ECM-receptor Interaction Pathway (119288); ECM-receptor Interaction Pathway (479)
size1 :
0.2 mL
price1 :
610 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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