product summary
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company name :
MyBioSource
product type :
antibody
product name :
p35, Baculovirus
catalog :
MBS6006015
quantity :
0.05 mL
price :
500 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
application :
western blot, immunohistochemistry, immunoprecipitation
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS6006015 image 1
Western Blot analysis of in vitro translated p35 baculovirus protein using MBS6006015 at 1:2000. Full-length p35 is detected at ~35kD, lower molecular p35 breakdown/cleavage bands are also detected.
product information
catalog number :
MBS6006015
products type :
Antibody
products full name :
p35, Baculovirus
products short name :
[p35, Baculovirus]
products name syn :
[Anti -p35, Baculovirus]
other names :
[P35]
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
specificity :
Recognizes p35 baculovirus.
purity :
Grade: Serum. Purity: Serum
form :
Supplied as a liquid, 0.05% sodium azide.
storage stability :
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
tested application :
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
app notes :
Suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Dilution: Western Blot: 1:1000-1:2000. p35 baculovirus may be observed as one or multiple bands. p35 baculovirus is cleaved during reaction with caspases. 10 and 25kD fragments have been described (3,4). Immunohistochemistry (FFPE): 1:1000-1:5000. Immunohistochemistry: Frozen sections. Immunoprecipitation: 1:50-1:200
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant corresponding to full-length p35 baculovirus protein.
products categories :
Antibodies; Abs to Infectious Disease
products description :
The baculoviruses are a large, diverse family of DNA viruses that have evolved a number of mechanisms to manipulate thier insect hosts. One of these is the ability to regulate apoptosis during infection by expressing proteins that can inhibit caspase activation, including the caspase inhibitor p35 and the inhibitor of apoptosis (IAP) proteins. The p35 baculovirus protein strongly inhibits caspase enzymatic activity, and is the the most broadly acting caspase inhibitor protein known. p35 baculovirus forms essentially irreversible complexes with its target caspases in a process that is accompanied by the cleavage of p35, generating two fragments of approximately 10kD and 25kD. These cleavage fragments remain associated with caspases and thereby block caspase activity. The ability of p35 to inhibit caspases along with the central role of caspases in the apoptotic process enables p35 baculovirus to block apoptosis in a phylogentically broad range of cells, and in response to a wide variety of apoptotic induction signals. For example, over expression of p35 in mammalian, insect, and nematode cells results in resistance to apoptosis.
ncbi gi num :
397133553
ncbi acc num :
AFO10087.1
size1 :
0.05 mL
price1 :
500 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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