RRBP1, CT (RRBP1, KIAA1398, Ribosome-binding protein 1, 180kD ribosome receptor homolog, ES/130-related protein, Ribosome receptor protein) | MyBioSource MBS6005375 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RRBP1, CT (RRBP1, KIAA1398, Ribosome-binding protein 1, 180kD ribosome receptor homolog, ES/130-related protein, Ribosome receptor protein)

catalog :

MBS6005375

quantity :

0.2 mL

price :

610 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

RRBP1 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the RRBP1 antibody detected the RRBP1 protein (arrow).

product information

catalog number :

MBS6005375

products type :

Antibody

products full name :

RRBP1, CT (RRBP1, KIAA1398, Ribosome-binding protein 1, 180kD ribosome receptor homolog, ES/130-related protein, Ribosome receptor protein)

products short name :

[RRBP1]

products name syn :

[Anti -RRBP1, CT (RRBP1, KIAA1398, Ribosome-binding protein 1, 180kD ribosome receptor homolog, ES/130-related protein, Ribosome receptor protein)]

other names :

[ribosome-binding protein 1; Ribosome-binding protein 1; ribosome-binding protein 1; ES/130-related protein; ribosome receptor protein; 180 kDa ribosome receptor homolog; ribosome binding protein 1 homolog 180kDa (dog); ribosome binding protein 1; 180 kDa ribosome receptor homolog; RRp; ES/130-related protein; Ribosome receptor protein]

other gene names :

[RRBP1; RRBP1; RRp; hES; ES130; ES/130; KIAA1398; RRp]

uniprot entry name :

RRBP1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

specificity :

Recognizes Human RRBP1 at ~152kD

purity :

Affinity Purified. Purified by Protein A affinity chromatography.

form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

concentration :

0.5 mg/ml

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

ELISA (EL/EIA), Western Blot (WB)

app notes :

Suitable for use in Western Blot, ELISA. Dilution: ELISA: 1:1,000. Western Blot: 1:1000. Optimal dilutions to be determined by the researcher.

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: Syntetic peptide corresponding to aa1327-1355, from the C-terminal region of human RRBP1, conjugated to KLH.

products categories :

Antibodies; Abs to Binding Proteins

products description :

Analysis of cDNA clones indicates that ribosome binding protein 1 may exist in different forms due to removal of tandem repeats, or partial intraexonic splicing of RRBP1. The form presented here is lacking the canine p180 ribosome-binding domain, NQGKKAEGAQ, which is tandemly repeated close to the N-terminus in other forms that haven't been fully characterized. RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome. Alternate splicing results in multiple transcript variants.

ncbi gi num :

110611220

ncbi acc num :

NP_004578.2

ncbi gb acc num :

NM_004587.2

uniprot acc num :

Q9P2E9

ncbi mol weight :

152,472 Da

ncbi pathways :

Protein Processing In Endoplasmic Reticulum Pathway (167325); Protein Processing In Endoplasmic Reticulum Pathway (167190)

ncbi summary :

This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]

uniprot summary :

RRBP1: a single-pass type III membrane protein of the rough endoplasmic reticulum membrane. Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. Associated with the unfolded protein response (UPR) and has anti-apoptotic activity. Knockdown of RRBP1 induces ER stress, and is associated with a significant reduction in the expression of glucose-regulated protein 78 (GRP78). GRP78 regulates the UPR, is widely upregulated in cancer, and plays an important role in chemotherapy resistance in some cancers. Upregulated in many cancers: overexpressed in a high proportion of breast carcinoma cases tested, and is highly expressed in lung cancer tissue compared with adjacent normal tissues. Because RRBP1 appears to play a role in tumor cell survival, it may be a candidate for new targeted therapeutics. Three human isoforms are produced by alternative splicing. Protein type: Translation; Ribosomal; Membrane protein, integral. Chromosomal Location of Human Ortholog: 20p12. Cellular Component: membrane; endoplasmic reticulum; integral to endoplasmic reticulum membrane; ribosome. Molecular Function: receptor activity. Biological Process: osteoblast differentiation; protein transport; translation

size1 :

0.2 mL

price1 :

610 USD

more info or order :

MyBioSource product webpage