PEMT, NT (PEMT, PEMPT, PNMT, Phosphatidylethanolamine N-methyltransferase, PEMT2) | MyBioSource MBS6004399 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PEMT, NT (PEMT, PEMPT, PNMT, Phosphatidylethanolamine N-methyltransferase, PEMT2)

catalog :

MBS6004399

quantity :

0.2 mL

price :

500 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS6004399

products type :

Antibody

products full name :

PEMT, NT (PEMT, PEMPT, PNMT, Phosphatidylethanolamine N-methyltransferase, PEMT2)

products short name :

PEMT

products name syn :

Anti -PEMT, NT (PEMT, PEMPT, PNMT, Phosphatidylethanolamine N-methyltransferase, PEMT2)

other names :

phosphatidylethanolamine N-methyltransferase isoform 3; Phosphatidylethanolamine N-methyltransferase; phosphatidylethanolamine N-methyltransferase; phosphatidylethanolamine N-methyltransferase; PEMT2

other gene names :

PEMT; PEMT; PNMT; PEAMT; PEMPT; PEMT2; PEMPT; PNMT; PEAMT; PEMT

uniprot entry name :

PEMT_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

specificity :

Recognizes human PEMT. Species Crossreactivity: mouse

purity :

Affinity Purified. Purified by ammonium sulfate precipitation

form :

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

concentration :

2.12mg/ml

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Suitable for use in Western Blot, Immunohistochemistry, ELISA. Dilution: Western Blot: 1:1,000; Immunohistochemistry (FFPE): 1:10-50

other info1 :

Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1-30 in the N-terminal region of human PEMT, UniProt Accession #Q9UBM1

other info2 :

Grade: Purified

products categories :

Antibodies; Abs to Enzymes, Methyltransferase

products description :

This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. The protein localizes to the endoplasmic reticulum and mitochondria-associated membranes. The gene is within the Smith-Magenis syndrome region on chromosome 17. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.

ncbi gi num :

388890237

ncbi acc num :

NP_001254481.1

ncbi gb acc num :

NM_001267552.1

uniprot acc num :

Q9UBM1

ncbi mol weight :

22,134 Da

ncbi pathways :

Acetylcholine Synthesis Pathway (198820); Glycerophospholipid Biosynthesis Pathway (645313); Glycerophospholipid Metabolism Pathway (82989); Glycerophospholipid Metabolism Pathway (364); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Phosphatidylcholine (PC) Biosynthesis, PE = PC Pathway (695051); Phosphatidylcholine (PC) Biosynthesis, PE = PC Pathway (468284); Phospholipid Metabolism Pathway (645312); Synthesis Of PC Pathway (645319)

ncbi summary :

Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

uniprot summary :

PEMT iso2: Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC). Belongs to the PEMT/PEM2 methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Lipid Metabolism - glycerophospholipid; Endoplasmic reticulum; Membrane protein, multi-pass; Mitochondrial; Methyltransferase; Membrane protein, integral; EC 2.1.1.71; EC 2.1.1.17. Chromosomal Location of Human Ortholog: 17p11.2. Cellular Component: endoplasmic reticulum membrane; mitochondrial membrane; integral to membrane. Molecular Function: phosphatidyl-N-methylethanolamine N-methyltransferase activity; phosphatidylethanolamine N-methyltransferase activity. Biological Process: methylation; cell proliferation; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine biosynthetic process; lipid metabolic process

size1 :

0.2 mL

price1 :

500 USD

more info or order :

MyBioSource product webpage