HLA Class 1 Antigen B12 (FITC) | MyBioSource MBS600362 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

HLA Class 1 Antigen B12 (FITC)

catalog :

MBS600362

quantity :

0.25 mL

price :

410 USD

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

[0.L.4]

reactivity :

human

application :

flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS600362

products type :

Antibody

products full name :

HLA Class 1 Antigen B12 (FITC)

products short name :

[HLA Class 1 Antigen B12]

products name syn :

[Anti -HLA Class 1 Antigen B12 (FITC)]

other names :

[HLA class I histocompatibility antigen, B-40 alpha chain; HLA class I histocompatibility antigen, B-7 alpha chain; major histocompatibility complex, class I, B; lymphocyte antigen; MHC class I antigen SHCHA; MHC Class I HLA heavy chain; MHC class I antigen GN00104; leukocyte antigen class I-B; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC class I antigen HLA-B heavy chain; HLA class I histocompatibility antigen, B alpha chain; major histocompatibility complex, class I, B; MHC class I antigen B*7]

other gene names :

[HLA-B; HLA-B; AS; HLAB; SPDA1; HLAB]

uniprot entry name :

1B07_HUMAN

clonality :

Monoclonal

isotype :

IgG2b

clone :

[0.L.4]

host :

Mouse

reactivity :

Human

specificity :

Recognizes human HLA Class 1 Antigen-B12.Sprecifity was determined at a 1:10 dilution bye the microcytotoxicity test under standard NIH conditions.

purity :

Highly Purified. Purified by Ion Exchange chromatography.

form :

Supplied as a liquid in PBS, 0.09% sodium azide, 1% BSA. Labeled with fluorescein isothiocyanate (FITC).

storage stability :

Store product at 4°C if to be used inmediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.<vAliquots are stable at -20°C for 12 months after receipt. Cautions: FITC conjugates are sensitive to light.For maximum recovery of product, centrifuge the original vial after thawing and prior to recoving the cap.

tested application :

Flow Cytometry (FC/FACS).

app notes :

Suitable for use in Flow Cytometry, Cell Typing, Tissue Staining and Chimerism Studies. Optimal Dilutions to be determined by the researcher.

other info1 :

Immunogen: HLA Class 1 Antigen-B12.

other info2 :

. FITC/Protein Ratio: 4.0-8.0

products categories :

Antibodies; Abs to HLA

products description :

Antibodies can also be used for the detection of HLA antigens on the lymphocytes in whole blood samples and cells isolated from blood or lymphoid tissue. The HLA Class 1 conjugated monoclonal antibodies can be used for the detection of specific cell surface antigens.

ncbi gi num :

416557

ncbi acc num :

Q04826.1

uniprot acc num :

P01889

ncbi mol weight :

40,460 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Cell Adhesion Molecules (CAMs) Pathway (83069)

ncbi summary :

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

uniprot summary :

HLAB iso7: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. Protein type: Immunoglobulin superfamily; Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: Golgi membrane; Golgi apparatus; phagocytic vesicle membrane; cell surface; membrane; endoplasmic reticulum; early endosome membrane; integral to plasma membrane; plasma membrane; integral to membrane; MHC class I protein complex. Molecular Function: peptide antigen binding; chaperone binding; TAP binding; receptor binding. Biological Process: regulation of immune response; viral reproduction; regulation of interleukin-12 production; detection of bacterium; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; defense response; protection from natural killer cell mediated cytotoxicity; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; regulation of T cell anergy; regulation of interleukin-6 production; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; immune response

size1 :

0.25 mL

price1 :

410 USD

more info or order :

MyBioSource product webpage