NALP3 (NACHT-, LRR- and PYD-Containing Protein 3, AGTAVPRL, AII/AVP, Angiotensin/Vasopressin Receptor AII/AVP-like, C1orf7, Cold Autoinflammatory Syndrome 1 Protein, CIAS1, Cryopyrin, Familial Cold Autoinflammatory Syndrome, FCAS, FCU, Muckle-Wells S | MyBioSource MBS600252 product information

product summary

request information :

company name :

MyBioSource

product type :

antibody

product name :

NALP3 (NACHT-, LRR- and PYD-Containing Protein 3, AGTAVPRL, AII/AVP, Angiotensin/Vasopressin Receptor AII/AVP-like, C1orf7, Cold Autoinflammatory Syndrome 1 Protein, CIAS1, Cryopyrin, Familial Cold Autoinflammatory Syndrome, FCAS, FCU, Muckle-Wells S

catalog :

MBS600252

quantity :

0.05 mg

price :

620 USD

clonality :

monoclonal

host :

mouse

reactivity :

human

application :

immunocytochemistry, western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS600252

products type :

Antibody

products full name :

products short name :

NALP3

products name syn :

Anti -NALP3 (NACHT-, LRR- and PYD-Containing Protein 3, AGTAVPRL, AII/AVP, Angiotensin/Vasopressin Receptor AII/AVP-like, C1orf7, Cold Autoinflammatory Syndrome 1 Protein, CIAS1, Cryopyrin, Familial Cold Autoinflammatory Syndrome, FCAS, FCU, Muckle-Wells Syndro

other names :

NACHT, LRR and PYD domains-containing protein 3 isoform d; AII/AVP receptor-like; NACHT, LRR and PYD domains-containing protein 3; cryopyrin; OTTHUMP00000038408; OTTHUMP00000038409; OTTHUMP00000038410; OTTHUMP00000038411; OTTHUMP00000230825; caterpiller protein 1.1; PYRIN-containing APAF1-like protein 1; NACHT, LRR and PYD containing protein 3; cold autoinflammatory syndrome 1 protein; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3; NLR family, pyrin domain containing 3; N/A

other gene names :

NLRP3; CIAS1; AII; AVP; FCU; MWS; FCAS; CIAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL; FLJ95925; N/A

uniprot entry name :

Q65Z67_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

9A11

host :

Host: Mouse; Source: Human

reactivity :

Human

specificity :

Recognizes endogenous human NALP3 at ~124kD.

purity :

Affinity Purified. Purified by affinity chromatography.

form :

Supplied as a liquid in PBS, 0.02% sodium azide.

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

Western Blot (WB), Immunocytochemistry (ICC)

app notes :

Suitable for use in Western Blot and Immunocytochemistry. Dilution: Western Blot: 1:1000. Immunocytochemistry: 1:100

other info1 :

Immunogen: Recombinant full length human NALP3. Cellular Localization: Cytoplasmic. Cellular Localization: Cytoplasmic

products categories :

Antibodies; Abs to Disease Markers

products description :

NALP3 is a cytoplasmic protein belonging to the NLRP family. NALP3 is involved in inflammation and immune response. Research indicates that NALP3 may function as an activator of NF-kappaB signalling and play a role in the regulation of inflammation and apoptosis. Mutations in the NALP3 gene have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). NALP3 is strongly expressed in polymorphonuclear cells, osteoblasts and chondrocytes, NALP3 can also be detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder.

ncbi gi num :

188536002

ncbi acc num :

NP_001120934.1

ncbi gb acc num :

NM_001127462.2

uniprot acc num :

Q65Z67

ncbi mol weight :

6,129 Da

ncbi pathways :

Immune System Pathway 106386!!Inflammasomes Pathway 366166!!Influenza A Pathway 217173!!Influenza A Pathway 217150!!Innate Immunity Signaling Pathway 106387!!NOD-like Receptor Signaling Pathway 122191!!NOD-like Receptor Signaling Pathway 122131!!Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways 366164!!Pertussis Pathway 218111!!Pertussis Pathway 218099

ncbi summary :

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq]

size :

0.05 mg

price :

620 USD

more info or order :

MyBioSource product webpage